A note on Poisson goodness-of-fit tests for ionizing radiation induced chromosomal aberration samples
A note on Poisson goodness-of-fit tests for ionizing radiation induced chromosomal aberration samples
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关于电离辐射引起的染色体畸变样品泊松拟合优度检验的说明
DOI：
10.1080/09553002.2018.1478012
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发表时间：
2018
影响因子：
2.6
通讯作者：
J. Barquinero
中科院分区：
文献类型：
--
作者：
M. Higueras;Jorge E. González;Marina Di Giorgio;J. Barquinero
摘要 目的：提出泊松精确拟合优度检验作为细胞遗传学生物剂量测定中最广泛使用的渐近 u 检验的替代和补充，以确定血细胞中染色体畸变样本是否来自均匀或不均匀暴露。材料和方法：引入文献中的三种泊松精确拟合优度检验并在 R 环境中实现。为了支持这项工作，已经更新了名为 GOF Poisson 的 Shiny R Studio 应用程序。三种精确检验和 u 检验适用于临床和意外辐射暴露患者的染色体畸变数据。结果：观察到，在染色体畸变率较小的小样本中，u 检验并不是一个合适的近似值。提供了工具来计算三个精确的测试，这并不像 u 测试的实现那么简单。结论：泊松精确拟合优度检验应与 u 检验联合考虑，以检测细胞遗传学生物剂量测定实践中的不均匀暴露。
Abstract Purpose: To present Poisson exact goodness-of-fit tests as alternatives and complements to the asymptotic u-test, which is the most widely used in cytogenetic biodosimetry, to decide whether a sample of chromosomal aberrations in blood cells comes from an homogeneous or inhomogeneous exposure. Materials and methods: Three Poisson exact goodness-of-fit test from the literature are introduced and implemented in the R environment. A Shiny R Studio application, named GOF Poisson, has been updated for the purpose of giving support to this work. The three exact tests and the u-test are applied in chromosomal aberration data from clinical and accidental radiation exposure patients. Results: It is observed how the u-test is not an appropriate approximation in small samples with small yield of chromosomal aberrations. Tools are provided to compute the three exact tests, which is not as trivial as the implementation of the u-test. Conclusions: Poisson exact goodness-of-fit tests should be considered jointly to the u-test for detecting inhomogeneous exposures in the cytogenetic biodosimetry practice.