EVIDENCE FOR A MONOCLONAL ORIGIN OF HUMAN ATHEROSCLEROTIC PLAQUES
EVIDENCE FOR A MONOCLONAL ORIGIN OF HUMAN ATHEROSCLEROTIC PLAQUES
复制标题
DOI：
10.1073/pnas.70.6.1753
复制
发表时间：
1973-01-01
影响因子：
11.1
通讯作者：
BENDITT, JM
中科院分区：
文献类型：
--
作者：
BENDITT, EP;BENDITT, JM
动脉粥样硬化斑块的主要细胞成分是平滑肌细胞。由于这些斑块在几个方面与它们在动脉壁下的前体不同，我们提出了一个问题：人类动脉粥样硬化斑块的起源是多克隆的还是单克隆的？杂合子女性的X-连锁葡萄糖-6-磷酸脱氢酶(EC 1.1.1.49)已被用来获得答案。对4例25~79岁女性患者的30块不同复杂程度的斑块和59例正常的主动脉和髂动脉壁进行了观察。数据显示，即使是直径为0.5厘米或更大的相对较大的动脉粥样硬化斑块的纤维帽，也是由单一或主要产生一种酶类型的细胞组成的，而小至0.1mm3的动脉壁中膜和内膜样本通常由多种细胞类型组成。如果斑块是对损伤的反应，类似于愈合的伤口，对生长刺激剂的反应，或者由于壁血栓的组织而形成，它们应该是多克隆的。因此，这些结果表明，人类动脉粥样硬化斑块的形成是由另一种机制引起的。与动脉粥样硬化斑块的单克隆性相适应的机制是突变，可能的原因是化学诱变剂或病毒。
The main cellular elements of atherosclerotic plaques are smooth muscle cells. Because these plaques differ from their precursors in the underlying artery wall in several ways, we have asked the question: Are human atherosclerotic plaques polyclonal or monoclonal in their origin? The X-linked glucose-6-phosphate dehydrogenase (EC 1.1.1.49) in heterozygotic females has been used to obtain an answer. 30 Plaques of different degrees of complexity and 59 samples of normal aorta and iliac artery walls from four females, 25-79 years old, were investigated. The data show that fibrous caps even of relatively large atheromatous plaques, 0.5 cm or greater in diameter, are composed of cells that produce solely or predominantly one enzyme type, whereas samples of artery wall media and intima as small as 0.1 mm3are regularly composed of a mixture of cell types. If plaques were a response to injury akin to a healing wound, a reaction to a growth stimulant, or formed due to an organization of a mural thrombus, they would be expected to be polyclonal. Hence, the results imply that atherosclerotic plaques in human beings arise by another mechanism. The mechanism compatible with the monoclonal nature of atherosclerotic plaques is mutation, and the likely causes are chemical mutagens or viruses.