Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice
Selectively Bred Diabetes Models: GK Rats, NSY Mice, and ON Mice
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DOI：
10.1007/978-1-0716-0385-7_3
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发表时间：
2020-01-01
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影响因子：
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通讯作者：
Eliasson, Lena
中科院分区：
文献类型：
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作者：
Nagao, Mototsugu;Esguerra, Jonathan Lou S.;Eliasson, Lena
选择性繁殖的糖尿病模型的多基因背景模拟2型糖尿病的病因。迄今为止，在糖尿病研究领域，通过从远交啮齿动物种群中连续选择性繁殖葡萄糖耐量，已经建立了三种不同的啮齿动物模型（Goto-Kakizaki大鼠、Nagoya-Shibata-Yasuda小鼠和Oikawa-Nagao小鼠）。这些啮齿类动物中高血糖症的起源主要是胰腺β细胞的胰岛素分泌不足和胰岛素靶器官中的轻度胰岛素抵抗。在本章中，我们总结了这些啮齿类动物模型的背景和表型，以突出它们在糖尿病研究中的重要性。然后，我们介绍实验方法来评估β细胞胞吐作为一个假定的共同缺陷，在这些啮齿动物模型中观察到的。
The polygenic background of selectively bred diabetes models mimics the etiology of type 2 diabetes. So far, three different rodent models (Goto-Kakizaki rats, Nagoya-Shibata-Yasuda mice, and Oikawa-Nagao mice) have been established in the diabetes research field by continuous selective breeding for glucose tolerance from outbred rodent stocks. The origin of hyperglycemia in these rodents is mainly insulin secretion deficiency from the pancreatic beta-cells and mild insulin resistance in insulin target organs. In this chapter, we summarize backgrounds and phenotypes of these rodent models to highlight their importance in diabetes research. Then, we introduce experimental methodologies to evaluate beta-cell exocytosis as a putative common defect observed in these rodent models.