Connective tissues: signalling by tenascins
Connective tissues: signalling by tenascins
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DOI：
10.1016/j.biocel.2004.01.007
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发表时间：
2004-06-01
影响因子：
4
通讯作者：
Tucker, RP
中科院分区：
文献类型：
--
作者：
Chiquet-Ehrismann, R;Tucker, RP
不同的结缔组织细胞分泌不同类型的腱链蛋白。这些糖蛋白有助于细胞外基质（ECM）的结构，并影响细胞与含有tenascin的环境接触的生理。Tenascin-C的表达受机械应力的调控。它在肿瘤周围的结缔组织、伤口和炎症组织中表达最高，它可能通过激活多种细胞内信号通路来调节细胞形态、生长和迁移。因此，整合素和syndecan信号传导受到tenascin-C的影响，并且参与细胞内信号传导途径的几种蛋白质的水平和/或活性受其存在的调节。Tenascin-X对真皮中胶原纤维的适当沉积很重要，Tenascin-X缺乏症患者患有Ehlers Danlos综合征。Tenascin-R（和-C）在神经系统中表现突出，对神经突生长和突触功能有影响，tenascin-W存在于骨、肌肉和肾脏的细胞外基质中。(C) 2004 Elsevier Ltd.版权所有。
Different connective tissue cells secrete different types of tenascins. These glycoproteins contribute to extracellular matrix (ECM) structure and influence the physiology of the cells in contact with the tenascin containing environment. Tenascin-C expression is regulated by mechanical stress. It shows highest expression in connective tissue surrounding tumors, in wounds and in inflamed tissues where it may regulate cell morphology, growth, and migration by activating diverse intracellular signalling pathways. Thus, integrin and syndecan signalling is influenced by tenascin-C and the levels and/or activies of several proteins involved in intracellular signalling pathways are regulated by its presence. Tenascin-X is important for the proper deposition of collagen fibers in dermis and patients with a tenascin-X deficiency suffer from Ehlers Danlos syndrome. Tenascin-R (and -C) is prominent in the nervous system and has an impact on neurite outgrowth and synaptic functions, and tenascin-W is found in the extracellular matrix of bone, muscle, and kidney. (C) 2004 Elsevier Ltd. All rights reserved.