PRESENCE OF NONSELECTIVE TYPE OF ENDOTHELIN RECEPTOR ON VASCULAR ENDOTHELIUM AND ITS LINKAGE TO VASODILATION
PRESENCE OF NONSELECTIVE TYPE OF ENDOTHELIN RECEPTOR ON VASCULAR ENDOTHELIUM AND ITS LINKAGE TO VASODILATION
复制标题
DOI：
10.1016/0014-5793(91)80454-b
复制
发表时间：
1991-04-22
期刊：
影响因子：
3.5
通讯作者：
NAWATA, H
中科院分区：
文献类型：
--
作者：
TAKAYANAGI, R;KITAZUMI, K;NAWATA, H
我们用内皮素（ET）（B）受体的特异性配体[Glu 9]-sarafotoxin S6 B（[Glu 9]SRTb）研究了非选择性ET（B）受体在血管中的作用。 含内皮的大鼠胸主动脉具有I-125-[Glu 9]SRTb的特异性结合位点，去除内皮后几乎消除，而内皮完整的大鼠主动脉中未检测到ET-3特异性结合位点。 在猪主动脉内皮细胞膜上仅检测到ET（B）受体。 [Glu 9]SRTb仅对大鼠主动脉环有舒张作用。 这些结果表明，ET（B）受体位于血管内皮上，并与血管舒张有关。
We studied the role of non-selective type (ET(B)) of endothelin (ET) receptor in the vasculature, using a ligand specific to the ET(B) receptor, [Glu9]-sarafotoxin S6b ([Glu9]SRTb). Endothelium-containing rat thoracic aorta possessed specific binding sites for I-125-[Glu9]SRTb, which were almost eliminated by removal of the endothelium, while ET-3-specific binding sites were not detected in the endothelium-intact rat aorta. Only ET(B) receptor was detected in the membranes from the endothelium of porcine aorta. [Glu9]SRTb exerted only vasodilation in rat aortic ring. These findings indicate that ET(B) receptors are located on vascular endothelium and linked to vasodilation.