Less but better: cardioprotective lipid profile of patients with GCK-MODY despite lower HDL cholesterol level.
Less but better: cardioprotective lipid profile of patients with GCK-MODY despite lower HDL cholesterol level.
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DOI：
10.1007/s00592-014-0567-1
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发表时间：
2014-08
影响因子：
3.8
通讯作者：
Mlynarski, Wojciech
中科院分区：
文献类型：
--
作者：
Fendler, Wojciech;Rizzo, Manfredi;Borowiec, Maciej;Malachowska, Beata;Antosik, Karolina;Szadkowska, Agnieszka;Banach, Maciej;Urbanska-Kosinska, Malgorzata;Szopa, Magdalena;Malecki, Maciej;Mlynarski, Wojciech
由单基因突变引起的糖尿病患者通常表现出糖尿病病程的改变。那些具有葡萄糖激酶基因（GCK-MODY）突变的人尽管高密度脂蛋白（HDL）胆固醇水平反而降低，但表现出良好的代谢控制和较低的心血管并发症风险。为了研究这个问题，我们分析了这些个体中低密度脂蛋白（LDL）和 HDL 亚群的组成。基于非变性线性聚丙烯酰胺凝胶电泳的 LipoPrint© 系统（Quantimetrix，美国）用于分离和测量来自葡萄糖激酶或 HNF1A 突变患者、1 型糖尿病 (T1DM) 和健康对照的新鲜冷冻血清样本中的 LDL 和 HDL 亚类。本研究测量了总共 37 名单基因糖尿病患者（21 名来自 GCK-MODY，16 名来自 HNF1A-MODY）、22 名 T1DM 患者和 15 名健康个体的新鲜血清样本。比较组中小的、高度致动脉粥样硬化的 LDL 亚群的浓度相似。 GCK-MODY 组中的大 HDL 百分比显着高于对照组 (p = 0.0003)、T1DM (p = 0.0006) 和 HNF1A-MODY 组 (p = 0.0246)。 GCK-MODY 患者的特点是中间 HDL 水平显着低于对照组 (p = 0.0003) 和 T1DM (p = 0.0005)。小的、潜在致动脉粥样硬化的 HDL 含量与 GCK-MODY 组显着不同，显示该亚组分的浓度与对照组 (p = 0.0096)、T1DM (p = 0.0193) 和 HNF1A-MODY (p = 0.0057) 组相比。组内异质性表明存在潜在的基因-基因或基因-环境相互作用。 GCK-MODY 的特点是对 HDL 胆固醇亚群具有强烈的保护作用。群体内一定程度的异质性表明与其他遗传或临床因素存在相互作用。
Patients with diabetes caused by single-gene mutations generally exhibit an altered course of diabetes. Those with mutations of the glucokinase gene (GCK-MODY) show good metabolic control and low risk of cardiovascular complications despite paradoxically lowered high-density lipoprotein (HDL) cholesterol levels. In order to investigate the matter, we analyzed the composition of low-density lipoprotein (LDL) and HDL subpopulations in such individuals. The LipoPrint© system (Quantimetrix, USA) based on non-denaturing, linear polyacrylamide gel electrophoresis was used to separate and measure LDL and HDL subclasses in fresh-frozen serum samples from patients with mutations of glucokinase or HNF1A, type 1 diabetes (T1DM) and healthy controls. Fresh serum samples from a total of 37 monogenic diabetes patients (21 from GCK-MODY and 16 from HNF1A-MODY), 22 T1DM patients and 15 healthy individuals were measured in this study. Concentrations of the small, highly atherogenic LDL subpopulation were similar among the compared groups. Large HDL percentage was significantly higher in GCK-MODY than in control (p = 0.0003), T1DM (p = 0.0006) and HNF1A-MODY groups (p = 0.0246). Patients with GCK-MODY were characterized by significantly lower intermediate HDL levels than controls (p = 0.0003) and T1DM (p = 0.0005). Small, potentially atherogenic HDL content differed significantly with the GCK-MODY group showing concentrations of that subfraction from control (p = 0.0096), T1DM (p = 0.0193) and HNF1A-MODY (p = 0.0057) groups. Within-group heterogeneity suggested the existence of potential gene–gene or gene–environment interactions. GCK-MODY is characterized by a strongly protective profile of HDL cholesterol subpopulations. A degree of heterogeneity within the groups suggests the existence of interactions with other genetic or clinical factors.
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影响因子：
3.5
作者：
Borowiec, M.;Fendler, W.;Mlynarski, W.
通讯作者：
Mlynarski, W.
影响因子：
8.2
作者：
Stride, Amanda;Shields, Beverley;Gill-Carey, Olivia;Chakera, Ali J.;Colclough, Kevin;Ellard, Sian;Hattersley, Andrew T.
通讯作者：
Hattersley, Andrew T.
DOI：
10.1207/s15374424jccp3303_19
发表时间：
2004-09-01
影响因子：
4.2
作者：
Keselman, HJ;Cribbie, RA;Holland, B
通讯作者：
Holland, B
影响因子：
7.2
作者：
Skupien, J.;Gorczynska-Kosiorz, S.;Malecki, M. -T.
通讯作者：
Malecki, M. -T.
影响因子：
7.7
作者：
Spégel P;Ekholm E;Tuomi T;Groop L;Mulder H;Filipsson K
通讯作者：
Filipsson K