Investigation on the optimal position for the quantification of hepatic perfusion by use of dynamic contrast-enhanced computed tomography in rats
Investigation on the optimal position for the quantification of hepatic perfusion by use of dynamic contrast-enhanced computed tomography in rats
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DOI：
10.1007/s12194-009-0063-4
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发表时间：
2009-07-01
影响因子：
1.6
通讯作者：
Murase, Kenya
中科院分区：
文献类型：
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作者：
Miyazaki, Shohei;Tachibana, Atsushi;Murase, Kenya
本研究的目的是通过双输入单室模型和动态对比增强计算机断层扫描（DCE-CT）研究大鼠肝脏灌注定量的最佳位置。在6只雄性Sprague-Dawley大鼠中，以仰卧位和俯卧位（间隔1天）对动物进行DCE-CT研究。计算下腔静脉（IVC）至门静脉的距离。利用主动脉、门静脉和肝脏的时间-密度曲线（TDC）估计肝动脉血流量（AHBF）和门静脉血流量（PHBF）。仰卧位下腔静脉与门静脉的距离（3.68 ± 0.22 mm）明显大于俯卧位下腔静脉与门静脉的距离（2.56 ± 0.19 mm）。估计的AHBF（102.1 +/- 8.9 ml/100 ml/min）和PHBF值（114.8 +/- 19.7 ml/100 ml/min）分别被显著高估和低估，与仰卧位相比（AHBF为76.1 ± 4.2 ml/100 ml/min，PHBF为235.1 ± 17.3 ml/100 ml/min）。我们的结论是，仰卧位比俯卧位更适合于使用双输入，单室模型和DCE-CT在大鼠肝脏灌注的定量，因为在门静脉中的TDC的影响较小，在IVC中的TDC在仰卧位比在俯卧位。
Our purpose in this study was to investigate the optimal position for the quantification of hepatic perfusion by using a dual-input, single-compartment model and dynamic contrast-enhanced computed tomography (DCE-CT) in rats. The DCE-CT studies were performed with the animals in the supine and prone position, with an interval of 1 day, on six male Sprague-Dawley rats. The distance between the inferior vena cava (IVC) and portal vein was calculated. The arterial hepatic blood flow (AHBF) and portal hepatic blood flow (PHBF) were also estimated by use of time-density curves (TDCs) in the aorta, portal vein, and liver. The distance between the IVC and portal vein in the supine position (3.68 +/- 0.22 mm) was significantly greater than that in the prone position (2.56 +/- 0.19 mm). The estimated AHBF (102.1 +/- 8.9 ml/100 ml/min) and PHBF values (114.8 +/- 19.7 ml/100 ml/min) in the prone position were significantly overestimated and underestimated, respectively, as compared to those in the supine position (76.1 +/- 4.2 ml/100 ml/min for AHBF and 235.1 +/- 17.3 ml/100 ml/min for PHBF). We concluded that the supine position was more appropriate than the prone position for the quantification of hepatic perfusion by use of a dual-input, single-compartment model and DCE-CT in rats, because the TDC in the portal vein is affected less by the TDC in the IVC in the supine position than in the prone position.