Application of near-infrared spectroscopy to measurement of hemodynamic signals accompanying stimulated saliva secretion
Application of near-infrared spectroscopy to measurement of hemodynamic signals accompanying stimulated saliva secretion
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DOI：
10.1117/1.3565048
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发表时间：
2011-04-01
影响因子：
3.5
通讯作者：
Koizumi, Hideaki
中科院分区：
文献类型：
--
作者：
Sato, Hiroki;Obata, Akiko N.;Koizumi, Hideaki
我们的目的是测试使用近红外光谱(NIRS)间接测量人类唾液分泌的可行性，以响应味觉刺激，从而潜在地应用于感官测试。我们使用NIRS系统来测量健康参与者在口腔中受到味觉刺激时的颅外血流动力学(太阳穴周围的HB信号)。首先，同时测量Hb信号和排出的唾液体积(由蒸馏水或蔗糖溶液刺激)，并发现Hb信号对味觉刺激的响应(Hb反应)。统计分析表明，蔗糖溶液的Hb反应和唾液量均大于蒸馏水，两者之间存在显著的相关性(r=0.81)。研究了吞咽对HB信号的影响。与蔗糖溶液和蒸馏水不同，即使参与者吞下口腔内容物，也能获得类似的Hb反应。最后，使用功能磁共振成像来识别与流涎相对应的Hb信号的可能来源。统计分析表明，颅外区域也有类似的反应，主要是在脑膜中动脉周围。综上所述，颅外血流动力学与唾液量之间的相关性表明，NIRS可用于测量伴随刺激唾液分泌的血流动力学信号。(C)2011年，光学仪器工程师学会。[DOI：10.1117/1.3565048]
We aim to test the feasibility of using near-infrared spectroscopy (NIRS) for indirect measurement of human saliva secretion in response to taste stimuli for potential application to organoleptic testing. We use an NIRS system to measure extracranial hemodynamics (Hb-signals around the temples) of healthy participants when taste stimuli are taken in their mouths. First, the Hb-signals and volume of expelled saliva (stimulated by distilled-water or sucrose-solution intake) are simultaneously measured and large Hb-signal changes in response to the taste stimuli (Hb-responses) are found. Statistical analysis show that both the Hb response and saliva volume are larger for the sucrose solution than for the distilled water with a significant correlation between them (r = 0.81). The effects of swallowing on the Hb-signals are investigated. Similar Hb responses, differing from the sucrose solution and distilled water, are obtained even though the participants swallow the mouth contents. Finally, functional magnetic resonance imaging is used to identify possible sources of the Hb signals corresponding to salivation. Statistical analysis indicates similar responses in the extracranial regions, mainly around the middle meningeal artery. In conclusion, the identified correlation between extracranial hemodynamics and the saliva volume suggests that NIRS is applicable to the measurement of hemodynamic signals accompanying stimulated saliva secretion. (C) 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3565048]