Prognostic significance of IL-17 mRNA expression in peritoneal lavage in gastric cancer patients who underwent curative resection
Prognostic significance of IL-17 mRNA expression in peritoneal lavage in gastric cancer patients who underwent curative resection
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DOI：
10.3892/or.2013.2911
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发表时间：
2014-02-01
期刊：
影响因子：
4.2
通讯作者：
Yamaue, Hiroki
中科院分区：
文献类型：
--
作者：
Iida, Takeshi;Iwahashi, Makoto;Yamaue, Hiroki
腹膜播散常见于晚期胃癌患者。腹膜腔是免疫宿主-肿瘤相互作用发生的隔室。胃癌患者腹腔灌洗液中IL-17的表达与预后的关系尚未见报道。因此，我们研究了胃癌患者腹腔灌洗液中IL-17 mRNA的表达，并评估其表达与临床病理参数和预后的关系。对114例胃癌患者进行了腹腔灌洗。79例患者行根治性切除。在79例患者中，IL-17 mRNA表达与肿瘤侵袭深度相关(P
Peritoneal dissemination is frequently detected in patients with advanced gastric cancer. The peritoneal cavity is a compartment in which an immunologic host-tumor interaction can occur. There are no reports on the relationship between IL-17 expression in peritoneal lavage and prognosis in gastric cancer patients. Therefore, we investigated the expression of IL-17 mRNA in peritoneal lavage from gastric cancer patients and assessed the association of its expression with clinicopathological parameters and prognosis. Peritoneal lavage was obtained from 114 patients with gastric cancer at initial surgery. Seventy-nine patients underwent curative resection. Among these 79 patients, IL-17 mRNA expression was associated with the depth of tumor invasion (P