Zolpidem-induced distortion in visual perception
Zolpidem-induced distortion in visual perception
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DOI：
10.1345/aph.1c318
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发表时间：
2003-05-01
影响因子：
2.9
通讯作者：
Lin, HY
中科院分区：
文献类型：
--
作者：
Huang, CL;Chang, CJ;Lin, HY
目的：描述一个病人谁开发的视觉感知失真后，一个单一剂量的zolpidem.CASE概要：一个50岁的亚洲妇女已规定共轭雌激素1片，每天激素替代治疗和磷酸三钙，每天两次骨质疏松症。一天，她服用唑吡坦10 mg治疗失眠，睡前服用对乙酰氨基酚500 mg治疗头痛，开始出现视知觉失真（例如，物体形状扭曲，房屋歪斜），持续约30分钟后视力恢复正常。她只是部分地回忆起这件事。她从来没有采取唑吡坦之前，她没有任何这样的干扰在paste.Discussion：有21例唑吡坦相关的精神病症状的文献报道，但是，唑吡坦可能导致视觉感知变化的确切机制是不确定的。许多因素与唑吡坦诱导的视觉体验相关，如药代动力学因素、性别、年龄和低白蛋白血症。这名患者有一定的相似之处，如性别，剂量，发病时间和持续时间的不良反应.CONCLUSIONS：一个客观的因果关系评估显示，唑吡坦引起的视觉感知失真在这名患者是可能的。临床医生应了解视知觉失真的可能性，因为这是一种不常见的不良反应。
OBJECTIVE: To describe a patient who developed visual perception distortion after a single dose of zolpidem.CASE SUMMARY: A 50-year-old Asian woman had been prescribed conjugated estrogen 1 tablet daily for hormone replacement therapy and tricalcium phosphate twice daily for osteoporosis. One day, she took zolpidem 10 mg for insomnia as well as acetaminophen 500 mg for headache at bedtime and began to have visual perception distortion (e.g., the shapes of objects were twisted, houses were crooked) within 20 minutes, lasting for approximately 30 minutes, and then her vision returned to normal. She only partially recalled the event. She had never taken zolpidem before, and she had not had any such disturbances in the past.DISCUSSION: There have been 21 case reports of zolpidem-related psychotic symptoms in the literature; however, the exact mechanism by which zolpidem may cause visual perception changes is undetermined. Many factors have been correlated with zolpidem-induced visual experiences, such as pharmacokinetic factors, gender, age, and hypoalbuminemia. This patient shared certain similarities such as gender, dosage, and time of onset and duration of adverse reactions.CONCLUSIONS: An objective causality assessment revealed that the zolpidem-induced visual perception distortion in this patient was probable. Clinicians should be aware of the potential for visual perception distortion, as this is an uncommon adverse effect.