Fat replacement of the malignant pancreatic tissue after neoadjuvant therapy
Fat replacement of the malignant pancreatic tissue after neoadjuvant therapy
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DOI：
10.1007/s10147-009-0001-9
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发表时间：
2010-02-01
影响因子：
3.3
通讯作者：
Coker, Ahmet
中科院分区：
文献类型：
--
作者：
Makay, Ozer;Kazimi, Mircelal;Coker, Ahmet
胰腺脂肪增多症的特征是胰腺组织的大量脂质浸润。虽然其病因不明确;肥胖、糖尿病、慢性胰腺炎、遗传性胰腺炎和引起胰腺导管阻塞的病症（例如肿瘤和结石）与其发病机制有关。最近，随着计算机断层扫描和磁共振成像的使用增加，观察胰腺的脂肪替代已经成为可能。在此，我们报告一位六十岁男性主诉腹痛及体重减轻。术前检查显示局部晚期（III期）胰腺癌。进行了多模式治疗，新辅助治疗后检测到100%完全缓解。患者接受了标准胰管切除术，无并发症。组织病理学显示胰腺脂肪增多症。在1年随访时，他无疾病，无复发。据我们所知，这是文献中首次报道的胰头癌与全脂肪替代胰腺后，新辅助放化疗。
Pancreatic lipomatosis is characterized as massive lipid infiltration of the pancreatic tissue. Although its etiology is ill defined; obesity, diabetes mellitus, chronic pancreatitis, hereditary pancreatitis, and conditions that cause pancreatic ductal obstruction, for example tumors and stones, are related to its pathogenesis. Recently, with the increased use of computerized tomography and magnetic resonance imaging, it has become possible to observe the fat replacement of the pancreas. Herein, we report a 60-year-old man complaining of abdominal pain and weight loss. Preoperative work-up revealed a locally advanced (Stage III) pancreatic adenocarcinoma. Multimodal treatment was carried out and a 100% complete response was detected after neoadjuvant therapy. The patient underwent a standard pancreaticoduodenectomy, without complications. The tissue pathology revealed lipomatosis of the pancreas. He was disease-free and symptom-free at 1 year follow-up. To our knowledge, this is the first report in the literature of pancreatic head carcinoma with total fat replacement of the pancreas after neoadjuvant chemoradiotherapy.