Venous Thrombosis in Blacks
Venous Thrombosis in Blacks
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DOI：
10.1161/circulationaha.111.073098
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发表时间：
2012-02-14
期刊：
影响因子：
37.8
通讯作者：
Key, Nigel S.
中科院分区：
文献类型：
--
作者：
Buckner, Tyler W.;Key, Nigel S.
837例(18%比10%)，正如预期的那样，因子V莱顿和凝血酶原基因突变在白人人群中更普遍。研究还表明，死于PE的黑人平均比死于PE的白人年轻9岁。这一发现表明，致命的院外PE患者与其他类型的VTE事件(孤立的远端DVT、近端DVT伴或不伴PE，或孤立的PE)之间可能存在重要的差异。VTE实际上可能是一种具有多种不同表型的疾病，每种表型在不同种族中的发病率和表达模式都不同。11.
837 (18% versus 10%), and as expected, factor V Leiden and prothrombin gene mutations were more prevalent in the white population. The study also showed that blacks who died as a result of PE were on average 9 years younger than whites who died of PE. This finding suggests that there may be important differences between patients with fatal out-of-hospital PE and those with other types of VTE events (isolated distal DVT, proximal DVT with or without PE, or isolated PE). VTE may in fact be a disease with multiple distinct phenotypes, each with a variable incidence and expression pattern in different ethnic groups. 11