Models of ovarian cancer metastasis: Murine models.
Models of ovarian cancer metastasis: Murine models.
复制标题
DOI：
10.1016/j.ddmod.2006.05.006
复制
发表时间：
2006-06-01
期刊：
影响因子：
--
通讯作者：
Orsulic, Sandra
中科院分区：
文献类型：
--
作者：
Sale, Sanja;Orsulic, Sandra
Mice have mainly been used in ovarian cancer research as immunodeficient hosts for cell lines derived from the primary tumors and ascites of ovarian cancer patients. These xenograft models have provided a valuable system for pre-clinical trials, however, the genetic complexity of human tumors has precluded the understanding of key events that drive metastatic dissemination. Recently developed immunocompetent, genetically defined mouse models of epithelial ovarian cancer represent significant improvements in the modeling of metastatic disease.
