B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis.
B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis.
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DOI：
10.1097/jto.0000000000000177
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Kwon ED
中科院分区：
文献类型：
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作者：
Mansfield AS;Roden AC;Peikert T;Sheinin YM;Harrington SM;Krco CJ;Dong H;Kwon ED
B7同系物1 [B7-H1;又名程序性细胞死亡1配体1（PD-L1）]是一种负性共刺激分子，与许多肿瘤类型的预后不良相关。鉴于间皮瘤的预后差和治疗有限，我们决定研究间皮瘤患者B7-H1表达及其与生存的关系。使用小鼠单克隆抗人B7-H1（克隆5 H1-A3）抗体和免疫组织化学测定106例患者中B7-H1的表达。阳性表达定义为阳性染色细胞≥5%。比较B7-H1阳性和阴性组的临床病理特征和生存率。42例（40%）恶性间皮瘤表达B7-H1。B7-H1阳性肿瘤患者不太可能接受或接受治疗性手术（p=0.03）。所有肉瘤样间皮瘤除了一个促结缔组织增生亚型表达B7-H1。与肿瘤不表达B7-H1的患者相比，肿瘤表达B7-H1的患者的生存期显著降低（中位数5个月，四分位距2-9.5个月）（14.5个月，9.25-19个月; p<0.0001）。在多变量模型中，B7-H1表达和肉瘤样间皮瘤仍然与较差的生存率显著相关[风险比分别为1.71，95%CI 1.03-2.78（p=0.04）和2.18，1.08-4.23（p=0.03）]。B7-H1在相当大比例的恶性胸膜间皮瘤中表达，并且与较差的存活率相关。几乎所有恶性胸膜间皮瘤肉瘤样分化表达B7-H1。B7-H1的表达可能对恶性胸膜间皮瘤的治疗有重要意义。
B7 homolog 1 [B7-H1; aka programmed cell death 1 ligand 1 (PD-L1)] is a negative costimulatory molecule that is associated with poor prognosis in many tumor types. Given the poor prognosis and the limited treatments available for mesothelioma, we decided to examine B7-H1 expression and its association with survival in patients with mesothelioma. Expression of B7-H1 was determined in 106 patients using a mouse monoclonal anti-human B7-H1 (clone 5H1-A3) antibody with immunohistochemistry. Positive expression was defined as ≥5% positively-stained cells. Clinicopathologic features and survival were compared between B7-H1 positive and negative groups. Malignant mesotheliomas of 42 patients (40%) expressed B7-H1. Patients with B7-H1-postive tumors were less likely to be offered or undergo therapeutic surgery (p=0.03). All sarcomatoid mesotheliomas except one desmoplastic subtype expressed B7-H1. Survival was significantly decreased for patients whose tumors expressed B7-H1 (5 months median, 2-9.5 months interquartile range) compared to those whose tumors did not (14.5 months, 9.25-19 months; p<0.0001). In a multivariate model, B7-H1 expression and sarcomatoid mesothelioma remained significantly associated with worse survival [risk ratio 1.71, 95% CI 1.03-2.78 (p=0.04) and risk ratio 2.18, 1.08-4.23 (p=0.03) respectively]. B7-H1 is expressed in a substantial proportion of malignant pleural mesotheliomas and is associated with poor survival. Almost all malignant pleural mesotheliomas with sarcomatoid differentiation expressed B7-H1. The expression of B7-H1 may have important therapeutic implications for the management of malignant pleural mesothelioma.