Entorhinal verrucae geometry is coincident and correlates with Alzheimer's lesions: a combined neuropathology and high-resolution ex vivo MRI analysis
Entorhinal verrucae geometry is coincident and correlates with Alzheimer's lesions: a combined neuropathology and high-resolution ex vivo MRI analysis
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DOI：
10.1007/s00401-011-0929-5
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发表时间：
2012-01-01
影响因子：
12.7
通讯作者：
Fischl, Bruce
中科院分区：
文献类型：
--
作者：
Augustinack, Jean C.;Huber, Kristen E.;Fischl, Bruce
内嗅皮层在第II层显示出独特的组织，并在其表面形成小凸起，称为内嗅疣。在阿尔茨海默病中，由于神经原纤维缠结形成和神经元死亡，疣状物消失。通过7.0 T扫描的高分辨率离体MRI体积重建等面模型，定量测量对照组和轻度阿尔茨海默病患者个体疣的高度、宽度、体积和表面积。在我们的认知正常（对照组）样本中，平均疣高度为0.13 +/- A 0.04 mm，而在轻度AD样本中，内嗅皮层（n = 10例）的平均高度为0.11 mm +/- A 0.05 mm （p < 0.001）。这些定量方法通过疣体高度和体积与疣体定性评分的显著相关性得到验证（n = 36例）。内嗅表面与其他皮质高度如扣带皮层、额叶皮层、枕叶皮层、顶叶皮层和颞叶皮层有显著差异。离体MRI证实了疣体与内嗅岛的共定位，并且疣体评分与Braak和Braak病理分期呈负相关。本研究描述了测量个体内嗅疣大小的新方法，并表明疣大小与阿尔茨海默病病理相关。综上所述，这些结果表明，疣可能有潜力作为轻度认知障碍和阿尔茨海默病的早期和特异性形态学标记。
Entorhinal cortex displays a distinctive organization in layer II and forms small elevations on its surface called entorhinal verrucae. In Alzheimer's disease, the verrucae disappear due to neurofibrillary tangle formation and neuronal death. Isosurface models were reconstructed from high-resolution ex vivo MRI volumes scanned at 7.0 T and individual verruca were measured quantitatively for height, width, volume, and surface area on control and mild Alzheimer's cases. Mean verruca height was 0.13 +/- A 0.04 mm for our cognitively normal (controls) sample set whereas for mild AD samples mean height was 0.11 mm +/- A 0.05 mm (p < 0.001) in entorhinal cortex (n = 10 cases). These quantitative methods were validated by a significant correlation of verrucae height and volume with qualitative verrucae ratings (n = 36 cases). Entorhinal surfaces were significantly different from other cortical heights such as, cingulate, frontal, occipital, parietal and temporal cortices. Colocalization of verrucae with entorhinal islands was confirmed in ex vivo MRI and, moreover, verrucae ratings were negatively correlated to Braak and Braak pathological stage. This study characterizes novel methods to measure individual entorhinal verruca size, and shows that verrucae size correlates to Alzheimer's pathology. Taken together, these results suggest that verrucae may have the potential to serve as an early and specific morphological marker for mild cognitive impairment and Alzheimer's disease.