Validation of UBE2C protein as a prognostic marker in node-positive breast cancer.
Validation of UBE2C protein as a prognostic marker in node-positive breast cancer.
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DOI：
10.1038/sj.bjc.6605122
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发表时间：
2009-07-07
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
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作者：
我们最近通过微阵列研究确定并验证了UBE2C RNA作为252例淋巴结阳性（N+）乳腺癌的预后标志物。本研究的目的是通过免疫组化（IHC）验证UBE2C蛋白作为N+乳腺癌的预后标志物。为此，使用了92块石蜡包埋块。评估UBE2C IHC值对无转移生存期（MFS）和总生存期（OS）的影响，并与Ki-67和诺丁汉预后指数（NPI）表现进行比较。根据基因组数据，UBE2C IHC对MFS和OS均有显著影响（风险比分别为6.79 - P=0.002和7.14 - P=0.009）。赤池信息标准证实UBE2C IHC的预后能力强于Ki-67（且与NPI接近）。此外，NPI的多变量分析显示，与Ki-67 IHC相反，UBE2C IHC仍然是MFS（校正P=0.02）和OS（校正P=0.04）的独立因素。我们证实IHC检测的UBE2C蛋白可以作为N+乳腺癌的预后标志物。UBE2C作为蛋白酶体活性标记物的潜在预测价值需要进一步研究。
We recently identified and validated UBE2C RNA as a prognostic marker in 252 node-positive (N+) breast cancers by means of a microarray study. The aim of this study was to validate UBE2C protein as a prognostic marker in N+ breast cancer by immunohistochemistry (IHC). To this end, 92 paraffin-embedded blocks were used. The impact of UBE2C IHC value on metastasis-free survival (MFS) and overall survival (OS) was evaluated and compared with Ki-67 and Nottingham prognostic index (NPI) performances. In accordance with genomic data, UBE2C IHC had a significant impact both on MFS and OS (hazard ratio=6.79 – P=0.002; hazard ratio=7.14 – P=0.009, respectively). Akaike information criterion proved that the prognostic power of UBE2C IHC was stronger than that of Ki-67 (and close to that of NPI). Furthermore, multivariate analyses with NPI showed that, contrary to Ki-67 IHC, UBE2C IHC remained an independent factor, both for MFS (adjusted P=0.02) and OS (adjusted P=0.04). We confirmed that UBE2C protein measured by IHC could be used as a prognostic marker in N+ breast cancer. The potential predictive interest of UBE2C as a marker of proteasome activity needs further investigations.
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影响因子：
6
作者：
Kauraniemi, P;Kuukasjärvi, T;Kallioniemi, A
通讯作者：
Kallioniemi, A
DOI：
10.1186/bcr2124
发表时间：
2008
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Wirapati P;Sotiriou C;Kunkel S;Farmer P;Pradervand S;Haibe-Kains B;Desmedt C;Ignatiadis M;Sengstag T;Schütz F;Goldstein DR;Piccart M;Delorenzi M
通讯作者：
Delorenzi M
影响因子：
3.8
作者：
Campone, Mario;Campion, Loic;Jezequel, Pascal
通讯作者：
Jezequel, Pascal
影响因子：
3.8
作者：
Deng, Shishan;Zhou, Hongying;Yang, Huijun
通讯作者：
Yang, Huijun
影响因子：
8
作者：
Wagner, KW;Sapinoso, LM;Hampton, GM
通讯作者：
Hampton, GM