Breast implant capsules are partially composed of bone marrow-derived cells.
Breast implant capsules are partially composed of bone marrow-derived cells.
复制标题
乳房植入物胶囊部分由骨髓来源的细胞组成。
DOI：
10.1097/01.sap.0000243996.37786.4a
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发表时间：
2007
影响因子：
1.5
通讯作者：
Isik,FFrank
中科院分区：
文献类型：
--
作者：
Isom,Casey;Kapoor,Vishal;Wilson,Lynne;Fathke,Carrie;Barnes,Leigh;Sullivan,StephenR;Isik,FFrank
乳房包膜挛缩是隆胸或假体再造后最常见的并发症。我们最近证明，骨髓来源的细胞在伤口愈合过程中为小鼠皮肤提供成纤维细胞。为了确定骨髓来源的细胞是否是假体周围胶囊的细胞来源，我们建立了嵌合C57BL小鼠，其中含有来自等基因增强绿色荧光蛋白（EGFP+）小鼠的骨髓细胞，并植入有纹理的硅胶壳植入物。我们发现没有小鼠发生感染或荚膜挛缩，但第30天的胶囊由26.4±6.1%的EGFP+细胞组成，第60天的胶囊由21.8±10.3%的EGFP+细胞组成。免疫组织化学显示胶囊中有少量EGFP+细胞，这些细胞是肌成纤维细胞。因此，乳房植入物胶囊部分由骨髓来源的细胞组成，并且考虑到这些细胞有可能成为肌成纤维细胞，这可能解释了当包膜挛缩发生时的细胞来源。在嵌合小鼠模型中，发现标记的骨髓细胞以肌成纤维细胞的形式存在于有纹理的硅胶植入物周围的假体胶囊中，这不仅表明了细胞的起源，而且表明了挛缩的潜在来源。
Capsular contracture is the most common complication following breast augmentation or reconstruction with implants. We recently demonstrated that bone marrow–derived cells provide fibroblasts to murine skin during wound healing. To determine if bone marrow–derived cells were the cellular source of periprosthetic capsules, we created chimeric C57BL mice containing bone marrow cells from isogeneic enhanced green fluorescent protein (EGFP+) mice and implanted with a textured silicone shell implant. We found that none of the mice developed infection or capsular contracture, but day 30 capsules were composed of 26.4±6.1% EGFP+ cells, and day 60 capsules had 21.8±10.3% EGFP+ cells. Immunohistochemistry revealed a small population of EGFP+ cells in the capsules that were myofibroblasts. Thus, breast implant capsules are partially composed of bone marrow–derived cells and, given the potential of these cells to become myofibroblasts, may explain the cellular source of capsular contracture when it develops.In a chimeric mouse model, marked bone marrow cells were found to exist as myofibroblasts in periprosthetic capsules around textured silicone implants, suggesting not only the origin of the cells but also a potential source of contracture.