Dynamics study of constant diastolic interval and constant TR control for cardiac alternans based on a two-dimensional cellular automata model
Dynamics study of constant diastolic interval and constant TR control for cardiac alternans based on a two-dimensional cellular automata model
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DOI：
10.1007/s11071-022-07821-9
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发表时间：
2022-09
影响因子：
5.6
通讯作者：
Min Xiong;Kai Sun;Xiaowen Su;E. Tolkacheva;Xiaopeng Zhao
中科院分区：
文献类型：
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作者：
Min Xiong;Kai Sun;Xiaowen Su;E. Tolkacheva;Xiaopeng Zhao
作为心律失常（如心房和心室颤动）的前兆，可能导致心脏性猝死，心脏电交替本质上是一种不稳定的心律，通常在快速起搏条件下发生心肌细胞的长和短动作电位持续时间（APD）交替。本文研究了基于全局伪心电图（ECG）的恒定TR控制方法，并与基于二维细胞自动机模型（CAM）的局部恒定舒张间期（DI）控制方法进行了比较，旨在预防或消除心律失常前的心脏电交替。结果表明，定TR和定DI控制方法都能有效地将交流发电机的基本周期长度（BCL）控制在较小的范围内。此外，这两种控制方法的功效取决于下扫协议中的“减小步长”Δ，并且较小的Δ可以显著提高它们的性能。此外，当采用相对大的Δ时，恒定TR控制在交替预防方面通常优于恒定DI控制上级。
As a precursor for cardiac arrhythmias such as atrial and ventricular fibrillations, which could cause sudden cardiac death, cardiac alternans is essentially an unstable heart rhythm with alternating long and short action potential durations (APD) of cardiac myocytes that usually occurs under fast pacing conditions. In this paper, the constant TR control method based on a global pseudo-electrocardiogram (ECG) is studied and compared with the local constant diastolic interval (DI) control method using a 2-dimensional (2-D) cellular automata model (CAM), aiming at preventing or eliminating cardiac alternans before arrhythmias. The results show that both the constant TR and constant DI control methods are effective in stabling the alternans to a smaller basic cycle length (BCL). Also, the efficacy of the two control approaches depends on the “decrease step” Δ in the downsweep protocol, and a smaller Δ could significantly improve their performance. In addition, constant TR control is generally superior to constant DI control in alternans prevention when a relatively large Δ is adopted.