Supramolecular chirality in peptide microcrystals.
Supramolecular chirality in peptide microcrystals.
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DOI：
10.1039/c4cc05002a
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发表时间：
2015-01
影响因子：
4.9
通讯作者：
D. Kurouski;Joseph D Handen;R. Dukor;L. Nafie;I. Lednev
中科院分区：
文献类型：
--
作者：
D. Kurouski;Joseph D Handen;R. Dukor;L. Nafie;I. Lednev
首次测定了纤维形成肽微晶的振动圆二色性（VCD）光谱。测量并比较了由同一肽，人胰岛淀粉样多肽（IAPP, amylin）形成的微晶和原纤维的VCD光谱。从这些光谱比较中获得了与微晶体和原纤维的超分子手性相关的结构信息，以及原纤维和微晶体的VCD增强机制。结论是，强增强VCD不需要编织两根或两根以上的细丝，这在原纤维中是允许的，但在微晶体中则不允许。
The vibrational circular dichroism (VCD) spectra of microcrystals of fibril-forming peptides have been measured for the first time. VCD spectra were measured and compared for microcrystals and fibrils formed from the same peptide, human islet amyloid polypeptide (IAPP, amylin). Structural information related to the supramolecular chirality of both the microcrystals and the fibrils, as well as the VCD enhancement mechanisms in fibrils and microcrystals, is obtained from these spectral comparisons. It is concluded that strongly enhanced VCD does not require braiding of two or more filaments that is permitted in fibrils but not microcrystals.