RECURRING CHROMOSOME-ABNORMALITIES IN HODGKINS-DISEASE
RECURRING CHROMOSOME-ABNORMALITIES IN HODGKINS-DISEASE
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DOI：
10.1002/gcc.2870050415
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发表时间：
1992-11-01
影响因子：
3.7
通讯作者：
ARTHUR, DC
中科院分区：
文献类型：
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作者：
DOHNER, H;BLOOMFIELD, CD;ARTHUR, DC
对33例霍奇金病患者的淋巴结或其他肿瘤进行了细胞遗传学分析。33例中25例获得了中期细胞。在9例病例中发现了可分析的异常克隆。特征性异常包括多倍性和复杂的结构重排非随机涉及某些染色体区域。最常获得的染色体是2、9、11、19和20，最常丢失的染色体是10、13、15、16、21和Y。易位断裂点聚集在条带1 p11 - 1 p13、1 p36、4 q35、14 q11和15 p11中。在5名患者中，断点位于T细胞受体基因已定位的条带中。未发现特异性、复发性易位。然而，1 q、4 q、6 q和17 p的染色体物质经常丢失。分别在5例和6例患者中发现4号和6号染色体丢失或缺失。缺失重叠，最小的重叠片段包括带4 q25 - 4 q27和6 q21 - 6 q23。这些数据表明，特定染色体区域的丢失可能在霍奇金病的发病机制中是重要的。关于肿瘤特异性，4 q的缺失是特别感兴趣的，因为这些先前没有报道在其他人类恶性肿瘤中非随机发生。
Cytogenetic analysis was performed on lymph nodes or other tumor masses from 33 patients with Hodgkin's disease. Metaphase cells were obtained in 25 of the 33 cases. Analyzable abnormal clones were found in nine cases. Characteristic abnormalities included polyploidy and complex structural rearrangements nonrandomly involving certain chromosomal regions. Chromosomes most commonly gained were 2, 9, 11, 19, and 20, and those most often lost were 10, 13, 15, 16, 21, and Y. Translocation breakpoints clustered in bands 1p11-1p13, 1p36, 4q35, 14q11, and 15p11. In five patients, breakpoints were in bands to which T-cell receptor genes have been mapped. No specific, recurring translocation was identified. There was, however, recurring loss of chromosomal material from 1q, 4q, 6q, and 17p. Loss or deletions of chromosomes 4 and 6 were found in five and six patients, respectively. Deletions overlapped, the smallest overlapping segments included bands 4q25-4q27 and 6q21-6q23. The data suggest that loss of specific chromosomal regions may be important in the pathogenesis of Hodgkin's disease. With respect to tumor specificity, deletions of 4q are of particular interest because these have not been previously reported to occur nonrandomly in other human malignancies.