Carcinogenic Potential of High Aspect Ratio Carbon Nanomaterials.
Carcinogenic Potential of High Aspect Ratio Carbon Nanomaterials.
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DOI：
10.1039/c5en00238a
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发表时间：
2016-06-01
期刊：
影响因子：
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通讯作者：
Rojanasakul Y
中科院分区：
文献类型：
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作者：
Luanpitpong S;Wang L;Davidson DC;Riedel H;Rojanasakul Y
工程纳米材料，包括高长径比碳纳米材料，通常在没有完整的人类风险评估和安全评估的情况下进行商业化。人们提出了健康问题，即长期吸入碳纳米管等高纵横比纳米材料可能会导致意想不到的健康后果，例如石棉样肺癌和间皮瘤。考虑到广泛的工业和临床应用以及人类接触纳米材料的发生率不断增加，及时解决纳米材料的致癌问题非常重要。本文综述了纳米材料遗传毒性和致癌性的最新进展，重点关注高长径比碳纳米管，并讨论了当前的知识差距和未来的研究方向。
Engineered nanomaterials, including high aspect ratio carbon nanomaterials, are often commercialized without a complete human risk assessment and safety evaluation. A health concern has been raised that high aspect ratio nanomaterials such as carbon nanotubes may cause unintended health consequences, such as asbestos-like lung cancer and mesothelioma, when chronically inhaled. Considering the widespread industrial and clinical applications and the increasing incidence of human exposure to nanomaterials, it is important to address the issue of nanomaterial carcinogenicity in a timely manner. This review summarizes recent advances in nanomaterial genotoxicity and carcinogenicity with a focus on high aspect ratio carbon nanotubes, and discusses current knowledge gaps and future research directions.