Dissociation between functional senescence and oxidative stress resistance in Drosophila
Dissociation between functional senescence and oxidative stress resistance in Drosophila
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DOI：
10.1016/s0531-5565(02)00096-7
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发表时间：
2002-12-01
影响因子：
3.9
通讯作者：
Grotewiel, MS
中科院分区：
文献类型：
--
作者：
Cook-Wiens, E;Grotewiel, MS
许多研究强烈表明，氧化应激与寿命决定之间存在因果联系。然而，氧化应激与年龄相关的功能衰退之间的关系还不是很清楚。此外，与衰老相关的功能衰退的全谱还没有在果蝇身上得到系统的评估，果蝇是衰老研究的领先模型之一。为了更全面地评估果蝇的功能衰老，我们评估了一系列年龄不断增长的对照果蝇的行为。我们的研究揭示了一种新的与年龄相关的嗅觉系统功能下降，并证实了先前关于苍蝇与年龄相关的运动缺陷的报道。对电击和光照的行为反应在老年果蝇中保持不变。因此，一些感觉系统在生命的最初几周会衰老，而另一些则不会。有趣的是，嗅觉和运动系统中与年龄相关的功能衰退在对照果蝇和麦氏变种中是难以区分的，玛氏变种对氧化应激的抵抗力增强，寿命延长。我们的结果表明，增强对氧化应激的抵抗力和延长寿命并不一定能防止与年龄相关的功能衰退。(C)2002 Elsevier Science Inc.保留所有权利。
Many studies strongly suggest a causal link between oxidative stress and determination of life span. The relationship between oxidative stress and age-related functional declines, however, is less clear. Additionally, the full spectrum of functional declines associated with aging has not been systematically evaluated in the fruit fly, Drosophila melanogaster, one of the leading models for aging research. Toward a more comprehensive assessment of functional senescence in Drosophila, we evaluated a series of behaviors in control flies of increasing ages. Our studies reveal a novel age-dependent functional decline in the olfactory system and confirm previous reports of age-related locomotor defects in flies. Behavioral responses to electric shock and light are maintained in aged flies. Thus, some sensory systems senesce during the first several weeks of life while others do not. Interestingly, the age-dependent functional declines in olfactory and locomotor systems are indistinguishable in control flies and methuselah, a mutant with enhanced resistance to oxidative stress and increased life span. Our results indicate that enhanced resistance to oxidative stress and extension of life span do not necessarily confer protection from age-related functional declines. (C) 2002 Elsevier Science Inc. All rights reserved.