Rh(II)-catalyzed intramolecular C-H insertion of diazo substrates in water: Scope and limitations
Rh(II)-catalyzed intramolecular C-H insertion of diazo substrates in water: Scope and limitations
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DOI：
10.1021/jo060397a
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发表时间：
2006-07-21
影响因子：
3.6
通讯作者：
Afonso, Carlos A. M.
中科院分区：
文献类型：
--
作者：
Candeias, Nuno R.;Gois, Pedro M. P.;Afonso, Carlos A. M.
优先Rh（II）类卡宾分子内C-H相对于O-H插入衍生自R-重氮乙酰胺，可以通过使用催化剂和酰胺基团的适当组合在水中实现，这在反应性类卡宾中心周围产生更大的疏水环境。
Preferential Rh(II) carbenoid intramolecular C-H versus O-H insertion derived from R-diazo-acetamides can be achieved in water by using an appropriate combination of the catalyst and amide groups, which creates a larger hydrophobic environment around the reactive carbenoid center.