Transcriptional profiling in the adrenal gland reveals circadian regulation of hormone biosynthesis genes and nucleosome assembly genes
Transcriptional profiling in the adrenal gland reveals circadian regulation of hormone biosynthesis genes and nucleosome assembly genes
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DOI：
10.1177/0748730406293053
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发表时间：
2006-10-01
影响因子：
3.5
通讯作者：
Eichele, Gregor
中科院分区：
文献类型：
--
作者：
Oster, Henrik;Damerow, Sebastian;Eichele, Gregor
视交叉上核的主昼夜节律起搏器通过中枢神经系统和全身器官中的附属外周振荡器的同步来协调行为和生理节律。在这些器官中，肾上腺占据主要地位，因为它们通过将儿茶酚胺和皮质激素节律性地分泌到血流中而对许多生理功能产生调节影响。在这份报告中，作者进行全基因组微阵列杂交，以表征昼夜转录组的小鼠肾上腺。他们表明，在这个腺体中，大约5%的小鼠基因组受到昼夜节律的控制。使用基因本体分析，他们确定了可能同步肾上腺激素生产的转录本类别。作者的表达谱分析还显示，涉及DNA复制或转录调控的多个组蛋白基因是时钟控制的，这表明生物钟可能通过一种新的方式调节染色质状态。
The master circadian pacemaker of the suprachiasmatic nuclei coordinates behavioral and physiological rhythms via synchronization of subordinate peripheral oscillators in the central nervous system and organs throughout the body. Among these organs, the adrenal glands hold a prime position because of their regulatory influence on numerous physiological functions via rhythmic secretion of catecholamines and corticoid hormones into the bloodstream. In this report, the authors perform whole genome microarray hybridization to characterize the circadian transcriptome of the murine adrenal. They show that similar to 5% of the mouse genome is under circadian control in this gland. Using gene ontology analysis, they identify classes of transcripts that may synchronize adrenal hormone production. The authors' expression profiling also revealed that multiple histone genes implicated in either DNA replication or transcriptional regulation are clock controlled, suggesting a novel way by which the circadian clock may regulate the chromatin state.