The critical size defect as an experimental model to test bone repair materials.
The critical size defect as an experimental model to test bone repair materials.
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DOI：
10.1097/00001665-199001000-00011
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发表时间：
1990-01-01
期刊：
影响因子：
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通讯作者：
Kleinschmidt, J C
中科院分区：
文献类型：
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作者：
Hollinger, J O;Kleinschmidt, J C
准确性和可重复性是科学方法的标志。科学方法经常被抛弃和短路。牙科和医疗材料及设备的开发和最终临床应用需要严格遵守科学方法。新型骨修复材料的开发也不例外。为测试新型骨修复材料提供了可靠、便捷、科学合理的评价体系。本综述描述了满足严格测试标准和评估分析方法的动物模型。回顾了实验设计、手术方案、定量组织学和 X 射线的组织制备以及生化评估。
Accuracy and reproducibility are the hallmarks of the scientific method. Too frequently, the scientific method is abandoned and short circuited. The development and eventual clinical application of dental and medical materials and devices requires strict adherence to scientific methodology. The development of new bone repair materials is no exception. A reliable, convenient, and scientifically sound evaluation system is available for testing new bone repair materials. Animal models that fulfill stringent testing criteria and analytical methodology for assessment are described in this review. Experimental design, surgical protocols, tissue preparation for quantitative histology and x-rays, and biochemical assessments are reviewed.