Dental plaque regrowth studies to evaluate chewing gum formulations incorporating magnolia bark extract
Dental plaque regrowth studies to evaluate chewing gum formulations incorporating magnolia bark extract
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DOI：
10.1016/j.jff.2017.08.016
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发表时间：
2017-10-01
影响因子：
5.6
通讯作者：
Higham, Susan M.
中科院分区：
文献类型：
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作者：
Komarov, Gleb N.;Hope, Christopher K.;Higham, Susan M.
在一项志愿者试验中，在 4 天的时间内食用各种无糖口香糖配方后，评估了厚朴提取物 (MBE) 的牙菌斑抑制特性。配对 t 检验表明，安慰剂和含有 MBE (0.4%) 加月桂酰胺精氨酸乙酯 (LAE) (0.5%) 的口香糖在斑块覆盖率百分比（36.3% vs 34.0%）和斑块荧光面积（109.4 mm(2) vs 75.2 mm(2)）方面存在显着差异（p < 0.15）。这些发现得到了唾液细菌总数（7.77 log 10 cfuiml vs 7.45 log 10 cfu/ml）以及链球菌属微生物计数的支持。 （6.76 logio cfuirn1 vs 6.29 logio cfu/ml）。口香糖释放的 MBE (0.4%) + LAE (0.5%) 对牙菌斑形成和唾液细菌有中等的抑制作用。限制牙菌斑和唾液细菌（特别是口腔链球菌）的形成，可能有助于改善牙龈疾病和龋齿的口腔健康。 (C) 2017 年作者。由爱思唯尔有限公司出版
The plaque inhibiting properties of magnolia bark extract (MBE) were assessed in a volunteer trial following the consumption of various sugar-free chewing gum formulations over a period of 4-days. Paired t-tests demonstrated significant (p < 0.15) differences between the placebo and a gum containing MBE (0.4%) plus lauramide arginine ethyl ester (LAE) (0.5%) with respect to% plaque coverage (36.3% vs 34.0%) and area of plaque fluorescence (109.4 mm(2) vs 75.2 mm(2)). These findings were supported by microbiological counts of total salivary bacteria (7.77 logio cfuiml vs 7.45 logio cfu/ml) as well as Streptococcus spp. (6.76 logio cfuirn1 vs 6.29 logio cfu/ml). MBE (0.4%) + LAE (0.5%) delivered by chewing gum had a moderate inhibitory effect on plaque formation and salivary bacteria. Limiting the formation of dental plaque and salivary bacteria, specifically oral streptococci, could contribute towards an improvement in oral health with respect to gum disease and caries. (C) 2017 The Authors. Published by Elsevier Ltd.