Decorin Suppresses Bone Metastasis in a Breast Cancer Cell Line
Decorin Suppresses Bone Metastasis in a Breast Cancer Cell Line
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DOI：
10.1159/000228253
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发表时间：
2009-01-01
期刊：
影响因子：
3.5
通讯作者：
Uchida, Atsumasa
中科院分区：
文献类型：
--
作者：
Araki, Kentaro;Wakabayashi, Hiroki;Uchida, Atsumasa
Decorin是一个不断扩大的富含亮氨酸的小蛋白聚糖家族的原型，参与了许多细胞过程，包括基质组装、纤维形成和细胞增殖的控制。在这项研究中，我们研究了decorin在抑制肿瘤侵袭性和骨转移中的作用。我们使用转移性乳腺癌细胞系MDA-MB-231，表明decorin在体外和体内都能引起明显的生长抑制。含有decorin转基因的巨细胞病毒载体导致细胞生长，运动和观察到的转移大大降低。转染decorin后，骨转移灶减少约90%。这些结果证明了decorin在乳腺癌模型中减少或预防肿瘤转移中的新作用，并可能最终导致转移性乳腺癌的治疗方法的改进。版权所有(C) 2009 S. Karger AG，巴塞尔
Decorin, the prototype of an expanding family of small leucine-rich proteoglycans, is involved in a number of cellular processes including matrix assembly, fibrillogenesis and the control of cell proliferation. In this study, we investigated the role of decorin in suppressing tumor aggressiveness and bone metastases. We used a metastatic breast cancer cell line, MDA-MB-231, to show that decorin causes marked growth suppression both in vitro and in vivo. A cytomegaloviral vector containing the decorin transgene caused greatly reduced cell growth, motility and observed metastases. Bone metastases were decreased by >90% upon decorin transfection. These results demonstrate a novel role for decorin in the reduction or prevention of tumor metastases in this breast cancer model and could eventually lead to improved therapies for metastatic breast cancer. Copyright (C) 2009 S. Karger AG, Basel