Checkpoint inhibitor immunotherapy for glioblastoma: current progress, challenges and future outlook.
Checkpoint inhibitor immunotherapy for glioblastoma: current progress, challenges and future outlook.
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DOI：
10.1080/17512433.2020.1817737
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发表时间：
2020-10
影响因子：
4.4
通讯作者：
Sampson JH
中科院分区：
文献类型：
--
作者：
Gedeon PC;Champion CD;Rhodin KE;Woroniecka K;Kemeny HR;Bramall AN;Bernstock JD;Choi BD;Sampson JH
Despite maximal surgical resection and chemoradiation, glioblastoma (GBM) continues to be associated with significant morbidity and mortality. Novel therapeutic strategies are urgently needed. Given success in treating multiple other forms of cancer, checkpoint inhibitor immunotherapy remains foremost amongst novel therapeutic strategies that are currently under investigation. Through a systematic review of both published literature and the latest preliminary data available from ongoing clinical studies, we provide an up-to-date discussion on the immune system in the CNS, a detailed mechanistic evaluation of checkpoint biology in the CNS along with evidence for disruption of these pathways in GBM, and a summary of available preclinical and clinical data for checkpoint blockade in GBM. We also include a discussion of novel, emerging targets for checkpoint blockade which may play an important role in GBM immunotherapy. Evidence indicates that while clinical success of checkpoint blockade for the treatment of GBM has been limited to date, through improved preclinical models, optimization in the context of standard of care therapies, assay standardization and harmonization, and combinatorial approaches which may include novel targets for checkpoint blockade, checkpoint inhibitor immunotherapy may yield a safe and effective therapeutic option for the treatment of GBM.
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影响因子：
3.7
作者：
Belcaid Z;Phallen JA;Zeng J;See AP;Mathios D;Gottschalk C;Nicholas S;Kellett M;Ruzevick J;Jackson C;Albesiano E;Durham NM;Ye X;Tran PT;Tyler B;Wong JW;Brem H;Pardoll DM;Drake CG;Lim M
通讯作者：
Lim M
影响因子：
2
作者：
Calkins, Hugh;Hindricks, Gerhard;Yamane, Teiichi
通讯作者：
Yamane, Teiichi
影响因子：
8.7
作者：
Allard B;Longhi MS;Robson SC;Stagg J
通讯作者：
Stagg J
细胞外嘌呤，嘌呤能受体和肿瘤生长。
影响因子：
8
作者：
Di Virgilio F;Adinolfi E
通讯作者：
Adinolfi E
影响因子：
32.4
作者：
Calzascia, T;Masson, F;Walker, PR
通讯作者：
Walker, PR