Socially induced morphine pseudosensitization in adolescent mice.
Socially induced morphine pseudosensitization in adolescent mice.
复制标题
DOI：
10.1097/fbp.0b013e328337be25
复制
发表时间：
2010-03
影响因子：
1.6
通讯作者：
Eitan S
中科院分区：
文献类型：
--
作者：
Hodgson SR;Hofford RS;Roberts KW;Wellman PJ;Eitan S
鉴于社会影响是青少年吸毒的最强预测因素之一，本研究考察了社会互动对青少年和成年小鼠吗啡诱导的过度运动的影响。检查三个实验组的青春期和成年雄性小鼠：1）吗啡处理的小鼠（每天两次，10-40 mg/kg，s.c.），2)将注射盐水的小鼠与吗啡处理的小鼠关在一起（“盐水笼友”），和3）将注射盐水的小鼠与吗啡处理的小鼠物理上和视觉上分开关在一起（“单独盐水”）。处理期后，单独测试小鼠对10 mg/kg吗啡（s.c.）的运动反应。青少年盐水笼队友，虽然第一次给予吗啡，表现出增强的hyper-motorization反应类似的运动敏感反应表现出吗啡治疗的小鼠。这在成年人中没有观察到。在成年动物中，单独使用生理盐水和使用生理盐水的笼友在吗啡诱导的过度运动方面没有显著差异。正如预期的那样，吗啡治疗的成人和青少年都表现出运动敏化。这些结果表明，在青春期的小鼠不存在于成年小鼠的社会影响的脆弱性。
Given that social influences are among the strongest predictors of adolescents’ drug use, this study examined the effect of social interaction on morphine-induced hyper-locomotion in both adolescent and adult mice. Three experimental groups of adolescent and adult male mice were examined: 1) morphine-treated mice (twice daily, 10–40 mg/kg, s.c.), 2) saline-injected mice housed together with the morphine-treated mice (‘saline cage-mates’), and 3) saline-injected mice housed physically and visually separated from the morphine-treated mice (‘saline alone’). Following the treatment period, mice were tested individually for their locomotor response to 10 mg/kg morphine (s.c.). Adolescent saline cage-mates, though administered morphine for the very first time, exhibited an enhanced hyper-locomotion response similar to the locomotor sensitization response exhibited by the morphine-treated mice. This was not observed in adults. In adults, there were no significant differences in morphine induced hyper-locomotion between saline alone and saline cage-mates. As expected, morphine-treated adults and adolescents both exhibited locomotor sensitization. These results demonstrate a vulnerability to social influences in adolescent mice which does not exist in adult mice.