Development and Validation of a Grading Scale for Primary Pontine Hemorrhage
Development and Validation of a Grading Scale for Primary Pontine Hemorrhage
复制标题
原发性脑桥出血分级量表的制定和验证
DOI：
10.1161/strokeaha.116.015326
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发表时间：
2017-01-01
期刊：
影响因子：
8.3
通讯作者：
Pan, Suyue
中科院分区：
文献类型：
--
作者：
Huang, Kaibin;Ji, Zhong;Pan, Suyue
背景和目的-我们的目的是开发和验证一个预测原发性脑桥出血（PPH）患者30天死亡率和90天功能结局的分级量表。方法-我们回顾性分析了2005年至2012年3家教学医院首次脑桥出血的连续患者的记录。通过logistic回归确定与30天死亡率相关的独立因素，以建立一个危险分层量表，命名为新的PPH评分。为了验证新的PPH评分，我们在2014年12月至2015年11月期间从10个单位前瞻性招募了受试者。新的PPH评分的性能提出的歧视和校准，测量的曲线下面积的接收器的工作特性和Hosmer-Lemeshow的拟合优度，分别为171例患者的数据可用于规模发展。新的PPH评分由2个独立因素组成，单个评分分配如下：格拉斯哥昏迷量表评分3 - 4（=2分）、5 - 7（=1分）和8 - 15（=0分）; PPH体积>10 mL（=2分）、5 - 10 mL（=1分）和
Background and Purpose-We aimed to develop and validate a grading scale for predicting 30-day mortality and 90-day functional outcome in patients with primary pontine hemorrhage (PPH).Methods-We retrospectively reviewed records of consecutive patients with first-ever pontine hemorrhage from 3 teaching hospitals between 2005 and 2012. Independent factors associated with 30-day mortality were identified by logistic regression to establish a risk stratification scale, named the new PPH score. For validation of the new PPH score, we prospectively recruited subjects from 10 units between December 2014 and November 2015. The performance of the new PPH score was presented as discrimination and calibration, measured by area under the curve of the receiver operating characteristic and Hosmer-Lemeshow goodness-of-fit, respectively.Results-Data of 171 patients were available for scale development. The new PPH score consisted of 2 independent factors with individual points assigned as follows: Glasgow Coma Scale score 3 to 4 (=2 points), 5 to 7 (=1 point), and 8 to 15 (=0 point); PPH volume >10 mL (=2 points), 5 to 10 mL (=1 point), and