High serum vascular endothelial growth factor correlates with disease activity of spondylarthropathies
High serum vascular endothelial growth factor correlates with disease activity of spondylarthropathies
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DOI：
10.1046/j.1365-2249.2003.02101.x
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发表时间：
2003-04-01
影响因子：
4.6
通讯作者：
Toussirot, É
中科院分区：
文献类型：
--
作者：
Drouart, M;Saas, P;Toussirot, É
血管生成参与慢性炎性关节疾病，如类风湿性关节炎（RA）。血管内皮生长因子（VEGF）在血管生成中起着至关重要的作用。脊椎关节病（SpA）的特征是附着点炎和滑膜炎，其中血管参与。本研究的目的是调查血清VEGF水平及其与SpA疾病活动标志物的潜在相关性。收集105例SpA患者（72例强直性脊柱炎（AS）、4例银屑病关节炎（PsA）、6例反应性关节炎（ReA）、8例肠病性关节病和15例未分化SpA）、50例类风湿关节炎（RA）和64例健康对照者的血清。使用Bath强直性脊柱炎疾病活动指数（BASDAI）和实验室炎症参数[红细胞沉降率（ESR）和C反应蛋白水平（CRP）]评估SpA患者的疾病活动性。SpA患者（316.4 ± 215.6 pg/ml）和RA患者（405.2 ± 366.5 pg/ml）的血清VEGF水平显著高于对照组（217.3 ± 145.2 pg/ml）（P = 0.003）。SpA患者血清VEGF水平与疾病活动指数相关（BASDAI：r = 0.22，P = 0.04; ESR：r = 0.3，P = 0.003; CRP：r = 0.23，P = 0.02）。血清VEGF水平与关节外表现、韧带赘生物或骶髂关节炎分级无关。这些结果表明，VEGF和血管生成可能在SpA的发病机制中发挥作用，并可作为SpA的疾病活动标志物。
Angiogenesis is involved in chronic inflammatory joint diseases such as rheumatoid arthritis (RA). Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis. The spondylarthropathies (SpA) are characterized by enthesitis and synovitis, in which blood vessels participate. The objective of this study was to investigate serum VEGF levels and their potential associations with disease activity markers for SpA. Sera were collected from 105 patients with SpA (72 with ankylosing spondylitis (AS), four with psoriatic arthritis (PsA), six with reactive arthritis (ReA), eight with enteropathic arthropathy and 15 with undifferentiated SpA), 50 patients with rheumatoid arthritis (RA) and 64 healthy controls. Disease activity in SpA patients was assessed using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and laboratory parameters of inflammation [erythrocyte sedimentation rate (ESR) and C-reactive protein level (CRP)]. Serum VEGF levels were significantly higher in SpA patients (316.4 +/- 215.6 pg/ml) and RA patients (405.2 +/- 366.5) than in controls (217.3 +/- 145.2) (P = 0.003). In SpA patients, serum VEGF levels correlated with disease activity indices (BASDAI: r = 0.22, P = 0.04; ESR: r = 0.3, P = 0.003; and CRP: r = 0.23, P = 0.02). Serum VEGF levels were not associated with presence of extra-articular manifestations or syndesmophytes or with the grade of sacroiliitis. These results suggest that VEGF and therefore angiogenesis may play a role in SpA pathogenesis and may serve as a disease activity marker in SpAs.