Synthesis of Novel Imidazo[1,2-a]pyridin-2-amines from Arylamines and Nitriles via Sequential Addition and I-2/KI-Mediated Oxidative Cyclization
Synthesis of Novel Imidazo[1,2-a]pyridin-2-amines from Arylamines and Nitriles via Sequential Addition and I-2/KI-Mediated Oxidative Cyclization
复制标题
通过顺序加成和 I-2/KI 介导的氧化环化从芳胺和腈合成新型咪唑并[1,2-a]吡啶-2-胺
DOI：
10.1002/chem.201600849
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Chang Junbiao
中科院分区：
文献类型：
--
作者：
Tian Xianhai;Song Lina;Wang Manman;Lv Zhigang;Wu Jie;Yu Wenquan;Chang Junbiao
本文提出了一种新颖实用的咪唑并[1，2-a]吡啶-2-胺骨架的合成方法。目前的顺序方法包括将芳胺加成到腈上，以及I2/KI介导的氧化C-N键形成，而无需纯化中间体脒。这种操作简单的合成方法以有效和可扩展的方式提供了容易获得各种新的2-氨基取代的咪唑并[1，2-a]吡啶和相关杂环化合物的途径。
A novel and practical strategy for the construction of imidazo[1,2‐a]pyridin‐2‐amine frameworks has been developed. The present sequential approach involves addition of arylamines to nitriles and I2/KI‐mediated oxidative C−N bond formation without purification of the intermediate amidines. This operationally simple synthetic process provides a facile access to a variety of new 2‐amino substituted imidazo[1,2‐a]pyridines and related heterocyclic compounds in an efficient and scalable fashion.