VOLUME AND ENERGY CONTENT OF MEALS AS DETERMINANTS OF GASTRIC-EMPTYING
VOLUME AND ENERGY CONTENT OF MEALS AS DETERMINANTS OF GASTRIC-EMPTYING
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DOI：
10.1113/jphysiol.1975.sp010841
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发表时间：
1975-01-01
影响因子：
5.5
通讯作者：
STUBBS, DF
中科院分区：
文献类型：
--
作者：
HUNT, JN;STUBBS, DF
1.结果收集自33项已发表和未发表的胃排空研究。 膳食的体积范围从50至1250毫升，其成分从纯碳水化合物到普通食物都有。 2.从公布的膳食组成，其营养密度，千卡/毫升。(4-18 KJ/ml）计算：范围为0至2 - 3 kcal/ml。 3.假设胃排空是指数的，测定30分钟内递送到十二指肠的每餐或试验餐的体积。 4.膳食的营养浓度越大，30分钟内转移到十二指肠的体积越少。min）。 5.用高营养密度的膳食减缓胃排空不足以防止用高营养密度的膳食增加输送到十二指肠的能量的速率（营养密度乘以单位时间内输送的体积）。 6.假设刺激（kcal/ml.）和十二指肠受体，有可能预测每餐的胃排空率，鉴于其营养密度。 知道了食物的初始体积，就有可能预测其排空的平均半衰期。 7.有八组异常结果：四组的进餐量少于200毫升。无法解释其他四项结果中的异常情况。 8.结果与等热量的脂肪、蛋白质和碳水化合物的消化产物的十二指肠作用使胃排空同等减慢一致，例如，4g脂肪或9 g碳水化合物，两者均为36千卡，碳水化合物和蛋白质为4千卡/克，脂肪为9千卡/克。
1. Results were collected from thirty‐three published and unpublished studies of gastric emptying. The volumes of the meals ranged from 50 to 1250 ml., and composition varied from pure carbohydrates to ordinary food. 2. From the published composition of the meals, their nutritive density, as kcal/ml. (4–18 KJ/ml.) was computed: it ranged from zero to 2‐3 kcal/ml. 3. The volume of each meal, or test meal, delivered to the duodenum in 30 min was determined, assuming that gastric emptying was exponential. 4. The greater the nutritive density of a meal, the less was the volume transferred to the duodenum in 30 min. The original volume of meal given was not a determinant of the rate of emptying (ml./min). 5. The slowing of gastric emptying with a meal of high nutritive density was not sufficient to prevent an increased rate of delivery of energy to the duodenum (nutritive density times volume delivered in unit time) with a meal of high nutritive density. 6. Assuming an appropriate relationship for the interaction of a stimulus (kcal/ml.) and duodenal receptors, it was possible to predict a rate of gastric emptying for each meal, given its nutritive density. Knowing the initial volume of the meal, it was possible to predict the mean half time for its emptying. 7. There were eight sets of anomalous results: in four the volumes of meal given were less than 200 ml.; explanations of the anomalies in the other four results could not be provided. 8. The results are consistent with equal slowing of gastric emptying by the duodenal action of the products of digestion of isocaloric amounts of fat, protein and carbohydrate, for example, 4 g fat or 9 g carbohydrate, both 36 kcal, taking carbohydrate and protein as 4 kcal/g and fat as 9 kcal/g.