Disaster-related prenatal maternal stress influences birth outcomes: Project Ice Storm
Disaster-related prenatal maternal stress influences birth outcomes: Project Ice Storm
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DOI：
10.1016/j.earlhumdev.2011.06.007
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发表时间：
2011-12-01
影响因子：
2.5
通讯作者：
King, Suzanne
中科院分区：
文献类型：
--
作者：
Dancause, Kelsey N.;Laplante, David P.;King, Suzanne
背景资料：先前的研究表明，产前母亲压力（PNMS）影响出生结果，但许多人类研究不能区分不同类型的压力源的影响或检查暴露时间对outcome.Objectives的影响：我们的目标是确定如何在怀孕期间暴露的时间和严重程度的客观和主观的压力，由于自然灾害影响妊娠期长度和胎儿生长模式。方法：我们评估了172名妇女在怀孕期间或怀孕前不久暴露于冰暴的客观和主观PNMS水平。我们分析了PNMS水平和结果之间的关联（妊娠长度，出生体重，出生长度，头围，和生长比率），控制其他变量，如年龄，产科并发症，社会经济地位，和特质anxiety.Results：妊娠长度和预测出生体重的参与者暴露于冰风暴在怀孕早期至中期，相比孕晚期和孕前暴露。与参考人群相比，样本中的出生长度较短，参与者的客观和主观PNMS水平之间存在“差异”，预测值较短。高的客观PNMS水平预测较小的头围在怀孕早期，但我们也观察到的头围与出生长度的比值的预测值的模式，这表明在怀孕早期的男孩之间的大脑发育相对于出生长度的节省。这些保留的影响下降，在以后的pregnancy.Conclusions：暴露于压力事件在怀孕期间影响出生的结果独立于其他因素。暴露时间，新生儿的性别，和类型的压力影响观察到的效果。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Background: Previous research suggests that prenatal maternal stress (PNMS) impacts birth outcomes, but many human studies cannot distinguish between the effects of different types of stressors or examine effects of exposure timing on outcomes.Objectives: Our goal was to determine how timing and severity of exposure during pregnancy to objective and subjective stress due to a natural disaster influenced gestation length and fetal growth patterns.Methods: We assessed objective and subjective PNMS levels among 172 women exposed to an ice storm during or shortly before pregnancy. We analyzed associations between PNMS levels and outcomes (gestation length, birth weight, birth length, head circumference, and growth ratios), controlling for other variables such as age, obstetric complications, socioeconomic status, and trait anxiety.Results: Gestation lengths and predicted birth weights were shorter among participants exposed to the ice storm during early to mid pregnancy, compared to 3 rd trimester and pre-pregnancy exposure. Birth lengths were shorter in the sample compared to population references, and predicted values were shorter among participants with a "discrepancy" between their objective and subjective PNMS levels. High objective PNMS levels predicted smaller head circumferences in early pregnancy, but we also observed patterns in predicted values of head circumference to birth length ratios suggesting the sparing of brain development relative to birth length among boys in early pregnancy. These sparing effects decreased in later pregnancy.Conclusions: Exposure to stressful events during pregnancy influences birth outcomes independently of other factors. Exposure timing, newborn sex, and the type of stressor influence the effects observed. (C) 2011 Elsevier Ireland Ltd. All rights reserved.