Smaller left Heschl's gyrus volume in patients with schizotypal personality disorder
Smaller left Heschl's gyrus volume in patients with schizotypal personality disorder
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DOI：
10.1176/appi.ajp.159.9.1521
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发表时间：
2002-09-01
影响因子：
17.7
通讯作者：
Shenton, ME
中科院分区：
文献类型：
--
作者：
Dickey, CC;McCarley, RW;Shenton, ME
目的：患有精神分裂症谱系障碍的个体表现出相似的遗传、神经递质、神经心理学、电生理学和结构异常。磁共振成像（MRI）研究表明，精神分裂型人格障碍患者的左颞上回（一个对语言处理很重要的区域）的灰质体积比匹配的对照受试者要小。在进一步的探索中，作者研究了颞上回的两个组成部分：Heschl 回和颞平面。 方法：从社区招募的 21 名从未服用过安定药物的男性受试者（符合 DSM-IV 精神分裂型人格障碍标准）和 22 名年龄相似的男性对照受试者中获得了 MRI 扫描。 21 名患有精神分裂型人格障碍的受试者中，有 18 名患有其他共病、非精神病诊断。在冠状图像上手动描绘颞上回，随后识别赫施尔回和颞平面，还进行了感兴趣区域体积与神经心理学测量之间的探索性相关性。结果：分裂型人格障碍受试者的左赫施尔回灰质体积比对照受试者小 21%，这一差异与共病 I 轴障碍的存在无关。右侧赫什尔回或右侧或左侧颞平面的体积没有组间差异，探索性分析还显示逻辑记忆不佳与左侧赫什尔回体积较小之间存在相关性。结论：精神分裂型人格障碍受试者的左侧赫什尔回灰质体积较小可能有助于解释先前报道的左侧颞上回异常，并可能是精神分裂症谱系障碍的脆弱性标志。
Objective: Individuals with schizophrenia spectrum disorders evince similar genetic, neurotransmitter, neuropsychological, electrophysiological, and structural abnormalities. Magnetic resonance imaging (MRI) studies have shown smaller gray matter volume in patients with schizotypal personality disorder than in matched comparison subjects in the left superior temporal gyrus, an area important for language processing. In a further exploration, the authors studied two components of the superior temporal gyrus: Heschl's gyrus and the planum temporale.Method: MRI scans were acquired from 21 male, neuroleptic-naive subjects recruited from the community who met DSM-IV criteria for schizotypal personality disorder and 22 male comparison subjects similar in age. Eighteen of the 21 subjects with schizotypal personality disorder had additional comorbid, nonpsychotic diagnoses. The superior temporal gyrus was manually delineated on coronal images with subsequent identification of Heschl's gyrus and the planum temporale, Exploratory correlations between region of interest volumes and neuropsychological measures were also performed.Results: Left Heschl's gyrus gray matter volume was 21% smaller in the schizotypal personality disorder subjects than in the comparison subjects, a difference that was not associated with the presence of comorbid axis I disorders. There were no between-group volume differences in right Heschl's gyrus or in the right or left planum temporale, Exploratory analyses also showed a correlation between poor logical memory and smaller left Heschl's gyrus volume.Conclusions: Smaller left Heschl's gyrus gray matter volume in subjects with schizotypal personality disorder may help to explain the previously reported abnormality in the left superior temporal gyrus and may be a vulnerability marker for schizophrenia spectrum disorders.