Different temporal trends of exposure to Bisphenol A among international travelers between Los Angeles and Beijing
Different temporal trends of exposure to Bisphenol A among international travelers between Los Angeles and Beijing
复制标题
洛杉矶与北京之间国际旅客双酚A暴露的不同时间趋势
DOI：
10.1016/j.envint.2020.105758
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发表时间：
2020-08-01
影响因子：
11.8
通讯作者：
Zhu, Yifang
中科院分区：
文献类型：
--
作者：
Lin, Yan;Qiu, Xinghua;Zhu, Yifang
最近的研究表明，美国人口接触双酚A（BPA）的趋势显着下降。然而，BPA暴露的时间趋势在中国仍然不清楚-一个人口众多的国家，有大量的工业活动，但在逐步淘汰消费品中的BPA方面所做的努力较少。此外，目前还不清楚从美国到中国的访问会在多大程度上影响人类对BPA的接触。在这个自然实验中，我们测量了从55名洛杉矶居民在2012年至2017年在北京度过10周之前，期间和之后重复收集的418份尿液样本中总BPA的浓度。我们发现，从洛杉矶到北京的旅行导致尿BPA水平增加了2.91倍（95% CI：2.43 - 3.50），在研究参与者回到洛杉矶后完全恢复到基线水平。从2012年到2017年，洛杉矶的尿BPA浓度每年下降25.5%（95% CI：-30.8%至-19.8%; p < 0.001），但在北京没有变化（p = 0.24）。因此，北京和洛杉矶之间的尿BPA浓度比从2012年的1.23（95%CI：0.82 - 1.85）增加到2017年的4.05（95%CI：2.75 - 5.97）。这些结果表明，在前往中国的国际旅行者中，BPA暴露可能会增加。中国需要进一步努力减少BPA的暴露。
Recent studies suggested a significant downward trend in population's exposure to bisphenol A (BPA) in the United States. However, the temporal trend of BPA exposure remains unclear in China - a populous country with substantial industrial activities but less efforts made to phase out BPA in consumer products. In addition, it is unclear to what extent a visit from the United States to China could affect human exposure to BPA. In this natural experiment, we measured the concentration of total BPA in 418 urine samples repeatedly collected from 55 Los Angeles residents before, during, and after they spent 10 weeks in Beijing from 2012 to 2017. We found that traveling from Los Angeles to Beijing led to a 2.91-fold (95% CI: 2.43 to 3.50) increase in urinary BPA levels, which fully returned to baseline after study participants came back to Los Angeles. From 2012 to 2017, urinary BPA concentrations decreased in Los Angeles by 25.5% per year (95% CI: -30.8% to -19.8%; p < 0.001) but did not change in Beijing (p = 0.24). Consequently, the concentration ratio of urinary BPA between Beijing and Los Angeles increased from 1.23 (95% CI: 0.82 to 1.85) in 2012 to 4.05 (95% CI: 2.75 to 5.97) in 2017. These results indicate that BPA exposures may increase among international travelers to China. Additional efforts are needed to reduce population's exposure to BPA in China.