Longitudinal decline in spoken word recognition and object knowledge in primary progressive aphasia.
Longitudinal decline in spoken word recognition and object knowledge in primary progressive aphasia.
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DOI：
10.1097/md.0000000000026163
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发表时间：
2021-06-04
期刊：
影响因子：
1.6
通讯作者：
Tippett DC
中科院分区：
文献类型：
--
作者：
Sikora J;Stein C;Ubellacker D;Walker A;Tippett DC
本研究的前提是，在语义变异型原发性进行性失语症 (PPA) (svPPA) 中，口语单词识别和物体知识会受到损害，而在语言减少变异型 (lvPPA) 和非流利语法不通的原发性进行性失语症 (nfaPPA) 中，在疾病发作时不会受到损害。然而，随着时间的推移，lvPPA 和 nfaPPA 的这些能力可能会存在异质性。我们假设，与文献中记录的那些患有 lvPPA 和 nfaPPA 的人相比，患有 svPPA 的个体在基线口语识别和物体知识方面的表现较差，但随着时间的推移，所有 3 个 PPA 变体的口语单词识别和物体知识下降率将相似，因为这些变体随着疾病进展而变得难以区分。本研究的目的是调查 PPA 变体中口语单词识别和物体知识下降的纵向模式。 95 名患有 PPA 的人在基线上完成了语义词图匹配和语义关联测试，以确定这些领域的预期表现。三十五人完成了后续测试。 lvPPA 和 svPPA 的对象知识三分平均下降率的分布相似 (P = .05)。 lvPPA 中，症状持续时间与语义词图匹配基线得分（r[37] = −0.399，P = .01）和语义关联基线得分（r[37] = −0.394，P = .01）之间存在弱负相关。在 lvPPA 中，随着时间的推移，口语单词识别和对象知识会出现退化。有必要进一步研究 PPA 中的接受性语言缺陷，以表征语言变化，从而减少 PPA 变体与疾病进展之间的差异。
The premise of this study is that spoken word recognition and object knowledge are impaired in semantic variant primary progressive aphasia (PPA) (svPPA) and are spared in logopenic variant (lvPPA) and nonfluent agrammatic primary progressive aphasia (nfaPPA) at disease onset. Over time, however, there may be heterogeneity in these abilities in lvPPA and nfaPPA. We hypothesized that individuals with svPPA would demonstrate poorer performance on baseline spoken word recognition and object knowledge than those with lvPPA and nfaPPA) as documented in the literature, but that rates of decline over time on spoken word recognition and object knowledge would be similar in all 3 PPA variants because these become less distinguishable with disease progression. The aim of this study was to investigate longitudinal patterns of decline in spoken word recognition and object knowledge across PPA variants. Ninety-five individuals with PPA completed the Semantic Word Picture Matching and Semantic Associates tests at baseline to establish expected performance in these areas. Thirty-five individuals completed follow-up testing. The distributions of trichotomized mean rates of decline in object knowledge were similar for lvPPA and svPPA (P = .05). There were weak negative correlations between symptom duration and baseline scores on Semantic Word Picture Matching (r[37] = −0.399, P = .01), and baseline scores on Semantic Associates (r[37] = −0.394, P = .01) in lvPPA. Degradation of spoken word recognition and object knowledge occurs over time in lvPPA. Further investigation of the receptive language deficits in PPA is warranted to characterize language changes that lessen the distinctions between PPA variants with disease progression.