RGD-Dependent Epithelial Cell-Matrix Interactions in the Human Intestinal Crypt.
RGD-Dependent Epithelial Cell-Matrix Interactions in the Human Intestinal Crypt.
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DOI：
10.1155/2012/248759
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Beaulieu JF
中科院分区：
文献类型：
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作者：
Benoit YD;Groulx JF;Gagné D;Beaulieu JF
细胞外基质（ECM）和整合素受体之间的相互作用触发细胞微环境和细胞骨架之间的结构和功能键。这种连接对于粘附结构的完整性是必不可少的，并且是调节特定细胞内信号转导的关键参与者，这反过来又调节细胞微环境的组织，从而调节细胞功能。RGD肽依赖性整联蛋白代表参与维持上皮稳态的ECM受体的关键亚组。在这里，我们回顾了最近的研究结果，RGD依赖ECM整合素的相互作用和它们在人类肠上皮隐窝细胞的作用。
Interactions between the extracellular matrix (ECM) and integrin receptors trigger structural and functional bonds between the cell microenvironment and the cytoskeleton. Such connections are essential for adhesion structure integrity and are key players in regulating transduction of specific intracellular signals, which in turn regulate the organization of the cell microenvironment and, consequently, cell function. The RGD peptide-dependent integrins represent a key subgroup of ECM receptors involved in the maintenance of epithelial homeostasis. Here we review recent findings on RGD-dependent ECM-integrin interactions and their roles in human intestinal epithelial crypt cells.