Reduced hippocampal volume in non-demented carriers of the apolipoprotein E ε4:: Relation to chronological age and recognition memory
Reduced hippocampal volume in non-demented carriers of the apolipoprotein E ε4:: Relation to chronological age and recognition memory
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DOI：
10.1016/j.neulet.2005.11.070
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发表时间：
2006-03-20
影响因子：
2.5
通讯作者：
Nyberg, L
中科院分区：
文献类型：
--
作者：
Lind, J;Larsson, A;Nyberg, L
载脂蛋白E epsilon 4(ApoE Epsilon 4)是已知的阿尔茨海默病(AD)的主要遗传危险因素。之前的一些研究报告了非痴呆APOE epsilon 4携带者的大脑结构变化和认知缺陷，但结果的模式不一致，需要进行更大样本量的研究。在这里，我们比较了APOE epsilon 4无症状携带者(N=30)和非携带者(N=30)(年龄范围：49-79岁)的海马体体积和识别记忆能力。我们观察到APOE 84携带者右侧海马体体积减小，发现这种差异在65岁之前最为明显。此外，APOE epsilon 4携带者在再认记忆测试中发出的错误警报明显更多，错误警报的数量与右侧海马体体积显著相关。这些结果表明，具有阿尔茨海默病遗传风险的相对年轻的个体海马体体积较小，在海马体依赖的认知任务中表现较差。未来的一个问题是，较小的海马体体积是否代表着早期发病的海马体体积减少，还是一种固有特征。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
Apolipoprotein E epsilon 4 (APOE epsilon 4) is the main known genetic risk factor for Alzheimer's disease (AD). Some previous studies have reported structural brain changes as well as cognitive deficits in non-demented APOE epsilon 4 carriers, but the pattern of results is inconsistent and studies with larger sample sizes have been called for. Here we compared hippocampal volume and recognition-memory performance between AD-symptom-free carriers (N = 30) and non-carriers (N = 30) of the APOE epsilon 4 (age range: 49-79 years). We observed reduced right hippocampal volume in APOE 84 carriers, and found that the difference was most pronounced before the age of 65. Further, the APOE epsilon 4 carriers made significantly more false alarms in the recognition-memory test, and the number of false alarms correlated significantly with right hippocampus volume. These results indicate that relatively young individuals at genetic risk for AD have smaller hippocampal volume and lower performance on hippocampal-dependent cognitive tasks. A question for the future is whether smaller hippocampal volume represents early-onset hippocampal volume reduction or an inherent trait. (c) 2005 Elsevier Ireland Ltd. All rights reserved.