EXTINCTION AND RECOVERY OF COCAINE SELF-ADMINISTRATION FOLLOWING 6-HYDROXYDOPAMINE LESIONS OF THE NUCLEUS ACCUMBENS
EXTINCTION AND RECOVERY OF COCAINE SELF-ADMINISTRATION FOLLOWING 6-HYDROXYDOPAMINE LESIONS OF THE NUCLEUS ACCUMBENS
复制标题
DOI：
10.1016/0091-3057(80)90166-5
复制
发表时间：
1980-01-01
影响因子：
3.6
通讯作者：
FIBIGER, HC
中科院分区：
文献类型：
--
作者：
ROBERTS, DCS;KOOB, GF;FIBIGER, HC
The effect of 6-OHDA injections into the nucleus accumbens was examined on cocaine self-administration behavior. Rats were given access to cocaine (0.75 mg/kg injection for 3 h/day on a continuous reinforcement schedule. After daily intake of cocaine had stabilized, rats were injected with 6-OHDA (8 .mu.g/2 .mu.l). When tested the day following the 6-OHDA injection most rats failed to self-administer cocaine, however this disruption did not resemble extinction. After several days self-administration recovered in many animals to near preoperative levels, and the rate of this recovery correlated (r = +0.75) with the levels of dopamine remaining in the nucleus accumbens. The animals with the greatest depletion of dopamine did not recover cocaine intake. In a separate experiment, animals were pretreated with demethylimipramine and/or pargyline to achieve a more extensive and selective lesion. When tested 5 days after the lesion all animals in these 6-OHDA groups showed a significant decline in cocaine intake compared to vehicle injected control animals. Several 6-OHDA treated animals displayed a pattern of behavior resembling extinction, where a high rate of lever pressing was followed by cessation of responding. Some animals were tested for apomorphine self-administration and this was not affected by the 6-OHDA treatment. The hypothesis that non-striatal dopamine may subserve cocaine reward was supported.
