Fluorescence imaging of hypochlorous acid and peroxynitrite in vitro and in vivo with emission wavelength beyond 750 nm.
Fluorescence imaging of hypochlorous acid and peroxynitrite in vitro and in vivo with emission wavelength beyond 750 nm.
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DOI：
10.1039/d0cc02322a
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发表时间：
2020-06
影响因子：
4.9
通讯作者：
Lin-fang Wang;Jing Liu;Shengwei Zhao;Hongxing Zhang;Yuanqiang Sun;A. Wei;W. Guo
中科院分区：
文献类型：
--
作者：
Lin-fang Wang;Jing Liu;Shengwei Zhao;Hongxing Zhang;Yuanqiang Sun;A. Wei;W. Guo
采用简单的三步程序合成了一系列近红外和光稳定的硅恶嗪荧光染料，其中一种还原产物氢硅恶嗪HSiO3已被用来灵敏地检测炎症和肺纤维化患病小鼠吞噬细胞产生的次氯酸和过氧亚硝酸盐，发射波长超过750 nm。
A series of near-infrared and photostable Si-oxazine fluorescent dyes was synthesized using a simple three-step procedure, and one of their reduced products, i.e. hydro-Si-oxazine HSiO3, has been utilized to sensitively detect hypochlorous acid and peroxynitrite generation by phagocytes in inflamed and pulmonary fibrosis diseased mice with emission wavelength beyond 750 nm.