Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues
Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues
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13-氧代紫杉素A的片段化及其在制备abeo-紫杉醇和abeo-多西紫杉醇类似物中的应用
DOI：
10.1016/j.tetlet.2010.11.008
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发表时间：
2011-01-05
影响因子：
1.8
通讯作者：
Zhao, Qin-Shi
中科院分区：
文献类型：
--
作者：
Zhao, Yu;Zhang, Hong-Bin;Zhao, Qin-Shi
分别用（t）BuOK和Red-Al处理的13-oxo-taxyunnansin A（3）的两个有趣的前所未有的片段已被发现、优化并成功地应用于新型abeo-紫杉醇和abeo-多西他赛衍生物的合成。合成了8个具有11（15 -> 1）-abeo-taxane骨架的abeo-paclitaxel和abeo-docetaxel衍生物，并对其抗癌活性进行了初步评价。(C)2010爱思唯尔有限公司版权所有。
Two interesting unprecedented fragmentations of 13-oxo-taxyunnansin A (3), initiated by treatment with (t)BuOK and Red-Al, respectively, have been discovered, optimized and successfully applied to the synthesis of novel abeo-paclitaxel and abeo-docetaxel derivatives. Eight new derivatives of abeo-paclitaxel and abeo-docetaxel possessing the structurally simplified 11 (15 -> 1)-abeo-taxane skeleton with an oxetane ring and pi bond conjugate system were accordingly prepared for the further evaluation of anticancer activities. (C) 2010 Elsevier Ltd. All rights reserved.