Breast Milk Microbiota Is Shaped by Mode of Delivery and Intrapartum Antibiotic Exposure
Breast Milk Microbiota Is Shaped by Mode of Delivery and Intrapartum Antibiotic Exposure
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母乳微生物群是由分娩方式和产时抗生素暴露形成的
DOI：
10.3389/fnut.2019.00004
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发表时间：
2019-02-04
影响因子：
5
通讯作者：
Rautava, Samuli
中科院分区：
文献类型：
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作者：
Hermansson, Henriina;Kumar, Himanshu;Rautava, Samuli
分娩方式被建议用来调节母乳的细菌组成，但产期使用抗生素对牛奶微生物区系的影响目前尚不清楚。本研究的目的是分析分娩方式和产中给药方式对母乳微生物组成的影响。产后1个月采集84例健康母亲的乳汁样本。总共有61名母亲经阴道分娩，其中23人接受了产中抗生素治疗，13名妇女接受了非选择性剖宫产，其中7人接受了抗生素治疗，10名母亲在没有接受分娩抗生素治疗的情况下进行了选择性剖宫产。通过相似性分析(ANOSIM)检验，分娩方式和产中抗生素暴露均与牛奶微生物组成的变化显著相关(p=0.001)。与产中接触抗生素相比，分娩方式对乳汁微生物区系组成的影响更深远。虽然目前对母乳微生物区系的临床意义知之甚少，但这项研究表明，剖宫产对母乳微生物区系组成有独立的影响。在剖腹产婴儿中观察到的微生态失调可能会因母乳微生物区系的异常而加重。
The mode of delivery has been suggested to modulate the bacterial composition of breast milk but the impact of intrapartum antibiotic use on the milk microbiota is currently not known. The aim of this study was to analyze the effects of the mode of the delivery and intrapartum antibiotic administration on the microbial composition of breast milk. Breast milk samples were collected from 84 healthy mothers 1 month after the delivery. In total, 61 mothers had delivered vaginally, 23 of which had received intrapartum antibiotics, 13 women had delivered with non-elective cesarean section, 7 of which had received antibiotics, and 10 mothers had delivered with elective cesarean section without intrapartum antibiotic treatment. Both mode of delivery and intrapartum antibiotic exposure were significantly associated with changes in the milk microbial composition as assessed by analysis of similarities (ANOSIM) test (p = 0.001). The mode of delivery had a more profound effect on the milk microbiota composition as compared to intrapartum antibiotic exposure. Although the clinical significance of breast milk microbiota is currently poorly understood, this study shows that cesarean section delivery has an independent effect on breast milk microbiota composition. The dysbiosis observed in infants born by cesarean section delivery may be aggravated by the aberrant breast milk microbiota.