Subcortical evidence for a contribution of arousal to fMRI studies of brain activity.
Subcortical evidence for a contribution of arousal to fMRI studies of brain activity.
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皮层的证据表明唤醒对脑活动的fMRI研究的贡献。
DOI：
10.1038/s41467-017-02815-3
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发表时间：
2018-01-26
影响因子：
16.6
通讯作者：
Duyn JH
中科院分区：
文献类型：
--
作者：
Liu X;de Zwart JA;Schölvinck ML;Chang C;Ye FQ;Leopold DA;Duyn JH
Cortical activity during periods of rest is punctuated by widespread, synchronous events in both electrophysiological and hemodynamic signals, but their behavioral relevance remains unclear. Here we report that these events correspond to momentary drops in cortical arousal and are associated with activity changes in the basal forebrain and thalamus. Combining fMRI and electrophysiology in macaques, we first establish that fMRI transients co-occur with spectral shifts in local field potentials (LFPs) toward low frequencies. Applying this knowledge to fMRI data from the human connectome project, we find that the fMRI transients are strongest in sensory cortices. Surprisingly, the positive cortical transients occur together with negative transients in focal subcortical areas known to be involved with arousal regulation, most notably the basal forebrain. This subcortical involvement, combined with the prototypical pattern of LFP spectral shifts, suggests that commonly observed widespread variations in fMRI cortical activity are associated with momentary drops in arousal. Resting cortical activity fluctuates, but it is unclear what underlies these variations in activity. Here, the authors show that large-scale fluctuations in fMRI cortical activity are associated with momentary decreases in cortical arousal and opposite activity changes in the basal forebrain and thalamus.
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影响因子：
3.4
作者：
Carbonell, Felix;Bellec, Pierre;Shmuel, Amir
通讯作者：
Shmuel, Amir
影响因子：
16.6
作者：
Anaclet C;Pedersen NP;Ferrari LL;Venner A;Bass CE;Arrigoni E;Fuller PM
通讯作者：
Fuller PM
影响因子：
2.5
作者：
Fukunaga, Masaki;Horovitz, Silvina G.;Duyn, Jeff H.
通讯作者：
Duyn, Jeff H.
影响因子：
2.5
作者：
Feige, B;Scheffler, K;Seifritz, E
通讯作者：
Seifritz, E
影响因子：
56.9
作者：
Buschman, Timothy J.;Miller, Earl K.
通讯作者：
Miller, Earl K.