The molecular physiology of electroneutral cation-chloride cotransport.
The molecular physiology of electroneutral cation-chloride cotransport.
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电中性阳离子-氯化物共转运的分子生理学。
DOI：
10.1007/s002329900255
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Hebert,SC
中科院分区：
文献类型：
--
作者：
Mount,DB;Hoover,RS;Hebert,SC
分子生物学在电中性阳离子-氯共转运体研究中的应用已经非常成功，导致鉴定了一个由五种膜蛋白组成的新基因家族。这些重要蛋白质的功能、表达和调控可以越来越多地用分子术语来描述。此外，在Bartter综合征和Gitelman综合征（肾盐排泄常染色体隐性遗传病）患者中发现了两种肾阳离子-氯转运体基因的突变。
The application of molecular biology to the study of electroneutral cation-chloride cotransporters has been extremely successful, resulting in the identification of a new gene family of five membrane proteins. The function, expression, and regulation of these important proteins can increasingly be described in molecular terms. In addition, mutations in two renal cation-chloride transporter genes have been found in patients with Bartter's and Gitelman's syndromes, autosomal recessive disorders of renal salt excretion.