IS OVARIAN ADRENERGIC-INNERVATION ESSENTIAL TO GONADAL-FUNCTION IN ADULT-RATS
IS OVARIAN ADRENERGIC-INNERVATION ESSENTIAL TO GONADAL-FUNCTION IN ADULT-RATS
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DOI：
10.3109/13813459509007572
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发表时间：
1995-04-01
影响因子：
3
通讯作者：
FAVARETTO, ALV
中科院分区：
文献类型：
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作者：
ALBUQUERQUEARAUJO, WIC;ROSAESILVA, AAM;FAVARETTO, ALV
我们研究了30、40、45和60日龄雌性大鼠性发育不同阶段卵巢神经支配的相对重要性。生后长期应用肾上腺素能神经元阻滞剂(Gd)促进化学交感神经切除。交感神经切断组大鼠青春期延迟，动情周期改变。除体外对促性腺激素的类固醇分泌反应降低外，30日龄时血中E(2)、LH和PRL水平均降低。另一方面，在60日龄大鼠中，观察到正常的垂体腺对LHRH的分泌反应和血浆促性腺激素浓度。这些数据强化了卵巢交感神经参与调节卵巢功能青春期前发育的观点。
We studied the relative importance of ovarian innervation during different phases of female rat sexual development, 30, 40, 45 and 60-day-old. Chemical sympathectomy was promoted by long term postnatal treatment with guanethidine (GD), an adrenergic neuron blocking agent. The sympathectomized rats exhibited delayed puberty and alterations in estrous cycle. Reduced circulating E(2), LH and Prl levels at 30 days of age were observed, besides decreased steroidal secretory responsiveness to gonadotropins in vitro. On the other hand, normal pituitary secretory responsiveness to LHRH in vivo and plasma gonadotropin concentrations were observed in 60-day-old rats. These data reinforce the view that ovarian sympathethic innervation contributes to the regulation of the prepubertal development of the ovarian functions.