Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16-64 years in Puerto Rico.
Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16-64 years in Puerto Rico.
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DOI：
10.1016/j.pvr.2018.03.006
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发表时间：
2018-06
期刊：
影响因子：
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通讯作者：
Unger ER
中科院分区：
文献类型：
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作者：
Ortiz AP;Tortolero-Luna G;Romaguera J;Pérez CM;González D;Muñoz C;González L;Marrero E;Suárez E;Palefsky JM;Panicker G;Unger ER
为了了解波多黎各妇女HPV暴露的危险因素，我们评估了居住在圣胡安大都市区的妇女的HPV 6、11、16和18血清学。作为一项横断面研究的一部分，524名年龄在16-64岁之间的未接种HPV疫苗的西班牙裔妇女完成了面对面和计算机辅助访谈，并提供了血液和自我收集的肛门和宫颈标本。血清学检测采用多重病毒样颗粒-IgG ELISA法，HPV DNA检测采用L1-consensus PCR法。二价（16/18）和四价（6/11/16/18）疫苗中HPV型别的血清学阳性率分别为32%和47%。型别特异性血清阳性率为HPV 6 − 29%，HPV 11 − 18%，HPV 16 − 23%和HPV 18 − 17%;血清阳性率在最年轻的年龄组中较高（16-19：26-37%）。HPV血清阳性与一生中有≥ 3个性伴侣（OR=2.5，95%CI =1.7-3.9）和肛门生殖器HPV DNA检测（OR=1.8，95%CI =1.2-2.6）相关。该西班牙裔人群中6/11/16/18型HPV疫苗的高累积暴露受到与通过性行为暴露HPV相关的因素的影响。最年轻年龄组的高血清阳性率表明波多黎各人乳头瘤病毒暴露的年龄较早，突出表明需要在16岁之前开始接种HPV疫苗。
To understand risk factors for HPV exposure in Puerto Rican women, we evaluated HPV 6, 11, 16, and 18 serology in women aged living in the San Juan metropolitan area. As part of a cross-sectional study, a population-based sample of 524 HPV unvaccinated Hispanic women ages 16–64 years completed face-to-face and computer assisted interviews and provided blood and self-collected anal and cervical specimens. Serology used multiplex virus-like particle based-IgG ELISA and HPV DNA was detected with L1-consensus PCR. 32% and 47% were seropositive to HPV types included in the bivalent (16/18) and quadrivalent (6/11/16/18) vaccines, respectively. Type-specific seroprevalence was HPV6 − 29%, HPV11 − 18%, HPV16 − 23%, and HPV18 − 17%; seroprevalence was high in the youngest age-group (16–19: 26–37%). HPV seropositivity was associated with having ≥ 3 lifetime sexual partners (OR=2.5, 95% CI=1.7–3.9) and detection of anogenital HPV DNA (OR=1.8, 95% CI=1.2–2.6). The high cumulative exposure of HPV vaccine types 6/11/16/18 in this Hispanic population was influenced by factors related to HPV exposure through sexual behavior. High seroprevalence in the youngest age-group indicates early age of exposure to HPV in Puerto Rico, highlighting the need for HPV vaccination starting prior to age 16.