A model for the function of sperm DNA degradation.
A model for the function of sperm DNA degradation.
复制标题
DOI：
10.1071/rd03072
复制
发表时间：
2004-07
期刊：
影响因子：
--
通讯作者：
M. Ward;W. Ward
中科院分区：
文献类型：
--
作者：
M. Ward;W. Ward
在这篇综述中，我们提出了我们最近的证据表明，但尚未证明，哺乳动物精子含有一种机制，通过这种机制，他们可以消化自己的DNA时，暴露在一个紧张的环境。我们讨论了我们最近的数据表明，当哺乳动物精子以各种方式处理时，受精卵中的父系染色体或精子DNA本身被降解成大的染色体大小的片段。这些已发表的数据支持精子中存在核酸酶活性。我们认为这种核酸酶活性是精子在遇到压力环境时使用的机制的一部分，以防止受精并避免将潜在受损的DNA传递给胚胎。我们提出了一个基于精子染色质结构的模型，通过该模型，这种核酸酶可以消化高度浓缩的精子染色质。
In this review, we present our recent evidence suggesting, but not yet proving, that mammalian spermatozoa contain a mechanism by which they can digest their own DNA when exposed to a stressful environment. We discuss our recent data that demonstrate that when mammalian spermatozoa are treated in a variety of ways, the paternal chromosomes in the zygote, or the sperm DNA itself, are degraded into large, chromosome-sized fragments. These published data support the existence of nuclease activity in spermatozoa. We suggest that this nuclease activity is part of a mechanism the spermatozoon uses when it encounters a stressful environment to prevent fertilisation and to avoid the transmission of potentially damaged DNA to the embryo. We propose a model based on sperm chromatin structure by which this nuclease can digest the highly condensed sperm chromatin.