C-reactive protein level is decreased in patients with Alzheimer's disease and related to cognitive function and survival time
C-reactive protein level is decreased in patients with Alzheimer's disease and related to cognitive function and survival time
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DOI：
10.1016/j.clinbiochem.2011.07.011
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发表时间：
2011-10-01
影响因子：
2.8
通讯作者：
Hultberg, Bjorn
中科院分区：
文献类型：
--
作者：
Nilsson, Karin;Gustafson, Lars;Hultberg, Bjorn
背景：先前的研究发现，与对照组或其他老年精神疾病患者诊断组相比，阿尔茨海默病（AD）患者血清CRP水平降低。方法：通过认知功能、脑成像和生存时间评估CRP水平与AD严重程度的关系。结果：AD患者总体CRP水平低于其他精神疾病患者，但CRP水平升高与认知功能低下和生存时间缩短相关。结论：CRP水平总体偏低的原因不明显。AD患者CRP水平升高表明该亚组患者存在炎症活动，可能从抗炎治疗中获益。(C) 2011加拿大临床化学学会。Elsevier Inc.出版。版权所有。
Background: Previous studies have observed decreased serum CRP levels in patients with established Alzheimer's disease (AD) compared to controls or other diagnostic groups of elderly patients with mental illness.Methods: We have investigated the relation between CRP level and the severity of AD as assessed by cognitive function, brain imaging and survival time.Results: Patients with AD showed overall lower CRP levels than other patients with mental illness, but elevated CRP levels in these patients were associated with lower cognitive function and shorter survival time.Conclusion: The reason for an overall low CRP level is not obvious. Elevated CRP level in patients with AD suggests the presence of inflammatory activity in this subgroup of patients that may benefit from antiinflammatory administration. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.