Different properties of visual relearning after damage to early versus higher-level visual cortical areas.
Different properties of visual relearning after damage to early versus higher-level visual cortical areas.
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DOI：
10.1523/jneurosci.0316-12.2012
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发表时间：
2012-04-18
期刊：
影响因子：
--
通讯作者：
Huxlin KR
中科院分区：
文献类型：
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作者：
Das A;Demagistris M;Huxlin KR
视知觉学习的操纵正在成为视觉系统损伤后的重要康复工具。训练刺激和任务属性的视觉学习的特异性已经在先前的工作中被用来推断高级别与低级别视觉皮层区域对这个过程的差异贡献。本研究采用了一个控制实验范式在猫，以检查是否重新学习的运动歧视和这种重新学习的特异性不同的影响，在较低与较高水平的视觉皮层层次的损害。对早期视觉区17、18和19或更高水平的运动处理外侧上裂（LS）皮质受损的猫进行训练，以执行受控固定的视觉任务。任何一种类型的病变的动物可以重新学习，以区分在其受损的视野中的漂移光栅和随机点刺激的运动方向。然而，有两个因素对于将学习转移到未经训练的运动刺激是至关重要的：（1）完整的LS皮层和（2）更复杂的视觉刺激。因此，虽然视觉皮层损伤的层次水平似乎并没有限制重新学习运动辨别的能力，但受损视觉系统的重新学习的普遍性似乎受到受损区域和训练期间使用的刺激的性质的影响。
The manipulation of visual perceptual learning is emerging as an important rehabilitation tool following visual system damage. Specificity of visual learning for training stimulus and task attributes has been used in prior work to infer a differential contribution of higher-level versus lower-level visual cortical areas to this process. The present study used a controlled experimental paradigm in felines to examine whether relearning of motion discrimination and the specificity of such relearning are differently influenced by damage at lower versus higher levels of the visual cortical hierarchy. Cats with damage to either early visual areas 17, 18, and 19, or to higher-level, motion-processing lateral suprasylvian (LS) cortex were trained to perform visual tasks with controlled fixation. Animals with either type of lesion could relearn to discriminate the direction of motion of both drifting gratings and random dot stimuli in their impaired visual field. However, two factors emerged as critical for allowing transfer of learning to untrained motion stimuli: (1) an intact LS cortex and (2) more complex visual stimuli. Thus, while the hierarchical level of visual cortex damage did not seem to limit the ability to relearn motion discriminations, generalizability of relearning with a damaged visual system appeared to be influenced by both the areas damaged and the nature of the stimulus used during training.